{"id":"5ad9d1d5-3da0-51f9-a2bb-7d388dd177ea","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-phytate-gradient","predicate":"dose_dependently_reduced","statement":"At added phytate-P levels of 0, 25, 50, 75, 100, 140, 175 and 250 mg, mean zinc absorption was 22%, 16%, 14%, 11%, 7%, 7%, 7% and 6%. Reductions were significant from 50 mg phytate-P in these meals.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2112790c-59f4-5809-9184-20a690765a71","mechanism_event_label":"Increasing phytate progressively reduced zinc uptake in the test meal.","subject":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"object":{"id":"957321e4-a5db-5a5d-851b-72069bab3efd","slug":"intestinal-zinc-absorption","display_name":"Intestinal zinc absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2112790c-59f4-5809-9184-20a690765a71","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-phytate-gradient-event","event_type":"observed_intervention","label":"Increasing phytate progressively reduced zinc uptake in the test meal.","description":"At added phytate-P levels of 0, 25, 50, 75, 100, 140, 175 and 250 mg, mean zinc absorption was 22%, 16%, 14%, 11%, 7%, 7%, 7% and 6%. Reductions were significant from 50 mg phytate-P in these meals.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"absorbed_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"meal_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"957321e4-a5db-5a5d-851b-72069bab3efd","slug":"intestinal-zinc-absorption","display_name":"Intestinal zinc absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc (absorbed_nutrient); Calcium (meal_context)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/hallberg2006.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"3a8556f5e4076009ed9adbf018205c8a3b2d0aaae43cccc866dc6be0271451d4\", \"utf8_bytes\": 1603}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human dual-radioisotope meal study: 40 subjects, 105 meals","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Wheat-roll meals contained 3.1 mg zinc and 266 mg calcium; added sodium phytate supplied 0–250 mg phytate phosphorus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Phytate-P mass is phosphorus mass, not total phytate mass. Seven-day calcium retention and zinc absorption are distinct endpoints; meal-specific significance levels are not universal thresholds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Increasing phytate progressively reduced zinc uptake in the test meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-hallberg2006] Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. (2006). https://pubmed.ncbi.nlm.nih.gov/16632176/ DOI: 10.1016/j.jtemb.2006.01.003","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal zinc absorption and whole-body calcium retention","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6d2dea92-d802-587a-9211-7717f8a2cf61","evidence_kind":"source_excerpt","locator":"Lines 1287-1300","start_line":1287,"end_line":1300,"excerpt":"### zn-clin-phytate-gradient\nAt added phytate-P levels of 0, 25, 50, 75, 100, 140, 175 and 250 mg, mean zinc absorption was 22%, 16%, 14%, 11%, 7%, 7%, 7% and 6%. Reductions were significant from 50 mg phytate-P in these meals.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Increasing phytate progressively reduced zinc uptake in the test meal.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal zinc absorption and whole-body calcium retention\nexperimental_model: Human dual-radioisotope meal study: 40 subjects, 105 meals\nlimitations: Phytate-P mass is phosphorus mass, not total phytate mass. Seven-day calcium retention and zinc absorption are distinct endpoints; meal-specific significance levels are not universal thresholds.\nexposure: Wheat-roll meals contained 3.1 mg zinc and 266 mg calcium; added sodium phytate supplied 0–250 mg phytate phosphorus.\ncross_nutrient: Zinc (absorbed_nutrient); Calcium (meal_context)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/hallberg2006.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"3a8556f5e4076009ed9adbf018205c8a3b2d0aaae43cccc866dc6be0271451d4\", \"utf8_bytes\": 1603}\n[zn-clin-hallberg2006] Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. (2006). https://pubmed.ncbi.nlm.nih.gov/16632176/ DOI: 10.1016/j.jtemb.2006.01.003","model_system":"Human dual-radioisotope meal study: 40 subjects, 105 meals","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-hallberg2006] Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. (2006). https://pubmed.ncbi.nlm.nih.gov/16632176/ DOI: 10.1016/j.jtemb.2006.01.003","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}