{"id":"5ac4025b-601d-54cc-92e4-1c26a8329a92","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mitochondrial-sam-entry","predicate":"transports","statement":"Human SLC25A26 imports cytosol-derived SAM into mitochondria for intramitochondrial methylation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c5c38c64-9424-58c4-b3be-d96089a7255e","mechanism_event_label":"Making SAM outside mitochondria is not enough; it must reach the organelle.","subject":{"id":"4f2c512b-583e-5a31-9c5f-bc699742f86e","slug":"slc25a26","display_name":"Human mitochondrial SAM transporter / SLC25A26","entity_type_key":"protein"},"object":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"c5c38c64-9424-58c4-b3be-d96089a7255e","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mitochondrial-sam-entry-event","event_type":"observed_relationship","label":"Making SAM outside mitochondria is not enough; 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species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Making SAM outside mitochondria is not enough; it must reach the organelle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26522469/ · DOI 10.1016/j.ajhg.2015.09.013","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Recorded as import of cytosol-derived SAM into mitochondria.","entity":null},{"dimension":"transport_pool","value_text":"the mitochondrial matrix","comparator":null,"unit":null,"notes":"Recorded as import of cytosol-derived SAM into mitochondria.","entity":null}],"evidence":[{"id":"910b311e-c8a3-514a-a3c9-d94b97179737","evidence_kind":"source_excerpt","locator":"Lines 108-114","start_line":108,"end_line":114,"excerpt":"## methionine-mitochondrial-sam-entry\nMaking SAM outside mitochondria is not enough; it must reach the organelle.\nHuman SLC25A26 imports cytosol-derived SAM into mitochondria for intramitochondrial methylation.\nModel: Human transporter-variant study with functional assays.\nLimitations: Transporter role and disease consequences are separately recorded.\nEvidence access: Primary abstract\nIntra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26522469/ · DOI 10.1016/j.ajhg.2015.09.013","model_system":"Human transporter-variant study with functional assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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