{"id":"5a70e371-3e2e-5ef7-b98f-b281c392bbf5","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-rat-enteral-iron-transfer","predicate":"supports","statement":"Riboflavin-deficient rats transferred less intragastrically administered 59Fe to plasma than age- or weight-matched controls.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"40286ce0-9e1a-5a68-bfe8-ad521f9bf007","mechanism_event_label":"Less of the administered iron reached the blood.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"40286ce0-9e1a-5a68-bfe8-ad521f9bf007","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-rat-enteral-iron-transfer-event","event_type":"biochemical_relationship","label":"Less of the administered iron reached the blood.","description":"Riboflavin-deficient rats transferred less intragastrically administered 59Fe to plasma than age- or weight-matched controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"radiotraced nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"B2 status changed systemic appearance of administered iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary riboflavin-deficient male rats versus age-/weight-matched controls; intragastric 59Fe and mucosal brush-border vesicles.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Dietary riboflavin deficiency plus intragastric 59Fe","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rat tracer experiment; does not establish an identical human absorption response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Less of the administered iron reached the blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[butler1993] Comparison of changes in the uptake and mucosal processing of iron in riboflavin-deficient rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8358336/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine and plasma","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"57ca77b1-0dd1-5c90-a70c-93043c92ac02","evidence_kind":"source_excerpt","locator":"Lines 1416-1428","start_line":1416,"end_line":1428,"excerpt":"### b2-rat-enteral-iron-transfer\nRiboflavin-deficient rats transferred less intragastrically administered 59Fe to plasma than age- or weight-matched controls.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Less of the administered iron reached the blood.\norganism: Rattus norvegicus\ntissue_or_cell_type: Intestine and plasma\nexperimental_model: Dietary riboflavin-deficient male rats versus age-/weight-matched controls; intragastric 59Fe and mucosal brush-border vesicles.\nlimitations: Rat tracer experiment; does not establish an identical human absorption response.\nexposure: Dietary riboflavin deficiency plus intragastric 59Fe\ncross_nutrient: B2 status changed systemic appearance of administered iron.\nevidence_location: Abstract\n[butler1993] Comparison of changes in the uptake and mucosal processing of iron in riboflavin-deficient rats. 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