{"id":"5a56bc90-8b2f-5191-b54a-7f1defe8fd25","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-gly-mammary-pup-growth","predicate":"reduced","statement":"Pups nursed by mammary Tmem165-deficient dams had impaired growth.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"160cd5e2-af21-5315-bb96-f83068603997","mechanism_event_label":"The milk-producing-cell defect was accompanied by slower growth in nursing pups.","subject":{"id":"987e2ba1-bcb7-55b9-9e09-d5dc915e51f1","slug":"mouse-mammary-tmem165-loss","display_name":"Mouse mammary epithelial TMEM165 loss","entity_type_key":"gene"},"object":{"id":"02ac885a-dfd8-58cd-9da0-709feeee242f","slug":"nursing-mouse-pup-growth","display_name":"Growth of nursing mouse pups","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"160cd5e2-af21-5315-bb96-f83068603997","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-gly-mammary-pup-growth-event","event_type":"observed_intervention","label":"The milk-producing-cell defect was accompanied by slower growth in nursing pups.","description":"Pups nursed by mammary Tmem165-deficient dams had impaired growth.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"befccab8-9951-58c0-bc59-2c13a789e6dc","slug":"mouse-tmem165","display_name":"Mouse TMEM165","entity_type_key":"protein"},"role":"affected_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"797e0616-8946-5497-b329-ab1f12ae7178","slug":"lactose","display_name":"Lactose","entity_type_key":"small_molecule"},"role":"affected_product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"987e2ba1-bcb7-55b9-9e09-d5dc915e51f1","slug":"mouse-mammary-tmem165-loss","display_name":"Mouse mammary epithelial TMEM165 loss","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"02ac885a-dfd8-58cd-9da0-709feeee242f","slug":"nursing-mouse-pup-growth","display_name":"Growth of nursing mouse pups","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Mouse TMEM165 (affected_protein); Lactose (affected_product)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-glycosylation-sources/milk2019.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"88bcb50ecdb918803c5950bcff8f48665dbd17148b365a4f9f3b463fe7edd2a4\", \"start_char\": 0, \"end_char\": 1462, \"text_sha256\": \"88bcb50ecdb918803c5950bcff8f48665dbd17148b365a4f9f3b463fe7edd2a4\", \"text_characters\": 1462}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional mammary epithelial Tmem165 deletion in mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tissue-specific deletion with milk composition and pup-growth measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The primary abstract supports normalized milk minerals and reduced lactose; altered concentration can reflect less milk dilution. 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