{"id":"5a554f6f-5c7c-5bc4-87ed-dcfcb2b69cd2","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-tpk1-deficiency-thdp","predicate":"reduces","statement":"TPK1-deficient patients had reduced ThDP in sampled muscle and blood; blood remained low during thiamine supplementation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a5b897b7-b619-5268-ac43-5b4ee993242e","mechanism_event_label":"Extra B1 intake does not guarantee normal cofactor production when activation machinery is impaired.","subject":{"id":"02591112-4d64-5ede-8760-2a7d67a6f3a9","slug":"tpk1-deficiency-genotypes","display_name":"Biallelic TPK1 deficiency genotypes","entity_type_key":"gene"},"object":{"id":"3bc55451-f499-5bef-9ab4-3c10a552b281","slug":"cellular-thdp-content","display_name":"Cellular thiamine diphosphate content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a5b897b7-b619-5268-ac43-5b4ee993242e","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-tpk1-deficiency-thdp-event","event_type":"observed_intervention","label":"Extra B1 intake does not guarantee normal cofactor production when activation machinery is impaired.","description":"TPK1-deficient patients had reduced ThDP in sampled muscle and blood; 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