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It is a fusion protein rather than native tubulin, which the authors address by the internal consistency of the two ligand classes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mebendazole","display_name":"Mebendazole","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Fungus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The drug really does stick to this protein, and the mutation that resists it loosens the grip.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mbz-p9736529] Fungal beta-tubulin, expressed as a fusion protein, binds benzimidazole and phenylcarbamate fungicides. 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It is a fusion protein rather than native tubulin, which the authors address by the internal consistency of the two ligand classes.\nexposure: Benzimidazole and phenylcarbamate binding to wild-type and Glu198Gly fusion protein\nevidence_span: {\"source_cache\": \"artifacts/mebendazole-research/9736529.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ee7cd2a364b52ba75f6f19da6935c7311ae80f514a223a50b17dbd6bbaf929d4\", \"start_char\": 0, \"end_char\": 1053, \"text_sha256\": \"ee7cd2a364b52ba75f6f19da6935c7311ae80f514a223a50b17dbd6bbaf929d4\"}\n[mbz-p9736529] Fungal beta-tubulin, expressed as a fusion protein, binds benzimidazole and phenylcarbamate fungicides. 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