{"id":"5a02c302-5dcf-53a3-afc0-1e11ff3e2719","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-human-spermine","predicate":"increases_measured_exposure","statement":"The same trial found increased plasma spermine exposure after oral spermidine.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d19146ba-6297-562e-af4a-2cc470b1e044","mechanism_event_label":"A related metabolite changed instead.","subject":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"object":{"id":"780b2405-9015-5555-be3b-c000fab5f680","slug":"human-plasma-spermine","display_name":"Human plasma spermine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d19146ba-6297-562e-af4a-2cc470b1e044","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-human-spermine-event","event_type":"observed_relationship","label":"A related metabolite changed instead.","description":"The same trial found increased plasma spermine exposure after oral spermidine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"780b2405-9015-5555-be3b-c000fab5f680","slug":"human-plasma-spermine","display_name":"Human plasma spermine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ded80d0b-9076-5034-9e87-cd38f7dafae5","slug":"spermine","display_name":"Spermine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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