{"id":"5976298f-c774-57df-b0d8-83936892f99b","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:ghana-child-diarrhea","predicate":"supplementation_associated_with_less","statement":"In the Ghana trial, lysine supplementation was associated with fewer child diarrheal episodes and illness days than placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c64fdca5-3349-5e80-963f-41cafcdc8872","mechanism_event_label":"A benefit appeared for this child morbidity endpoint in the studied community.","subject":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"object":{"id":"d94f2449-7514-574c-8cc8-6c3f826d139c","slug":"child-diarrheal-morbidity","display_name":"Child diarrheal morbidity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c64fdca5-3349-5e80-963f-41cafcdc8872","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:ghana-child-diarrhea-event","event_type":"observed_intervention","label":"A benefit appeared for this child morbidity endpoint in the studied community.","description":"In the Ghana trial, lysine supplementation was associated with fewer child diarrheal episodes and illness days than placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d94f2449-7514-574c-8cc8-6c3f826d139c","slug":"child-diarrheal-morbidity","display_name":"Child diarrheal morbidity","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d7a860ea-b5a2-5a8a-b75b-70c2f8d109a3","slug":"child-diarrheal-episodes","display_name":"Child diarrheal episodes","entity_type_key":"cellular_process"},"role":"decreased_outcome","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"65441385-8efe-5499-8a03-1b4d9c0ffaa4","slug":"child-diarrheal-illness-days","display_name":"Child diarrheal illness days","entity_type_key":"cellular_process"},"role":"decreased_outcome","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Randomized placebo-controlled community trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Context-specific clinical result; does not establish receptor antagonism, intestinal repair mechanism, or broad infection prevention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A benefit appeared for this child morbidity endpoint in the studied community.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ghosh2010] Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana (2010). https://www.sciencedirect.com/science/article/pii/S0002916523019640 DOI: 10.3945/ajcn.2009.28834","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastrointestinal illness outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4fddfed9-5527-50b1-bc9d-7ad48749a446","evidence_kind":"source_excerpt","locator":"Lines 719-727","start_line":719,"end_line":727,"excerpt":"### ghana-child-diarrhea\nIn the Ghana trial, lysine supplementation was associated with fewer child diarrheal episodes and illness days than placebo.\nPlain language: A benefit appeared for this child morbidity endpoint in the studied community.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Gastrointestinal illness outcomes\nexperimental_model: Randomized placebo-controlled community trial\nlimitations: Context-specific clinical result; does not establish receptor antagonism, intestinal repair mechanism, or broad infection prevention.\n[ghosh2010] Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana (2010). https://www.sciencedirect.com/science/article/pii/S0002916523019640 DOI: 10.3945/ajcn.2009.28834","model_system":"Randomized placebo-controlled community trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [ghosh2010] Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana (2010). https://www.sciencedirect.com/science/article/pii/S0002916523019640 DOI: 10.3945/ajcn.2009.28834","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}