{"id":"5948a8cf-da6d-56e6-b2b1-e4a3215a4e1b","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-ck2-zip7","predicate":"phosphorylated","statement":"The study identified CK2-dependent phosphorylation of ZIP7 as a regulatory step preceding cytosolic zinc release from intracellular stores.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"95b91869-d996-5739-af6c-3f69143a13c1","mechanism_event_label":"A kinase can open the route from stored zinc to a cytoplasmic signal.","subject":{"id":"4ceda93e-2b3b-5d47-8eea-34ff2c531518","slug":"ck2","display_name":"Human protein kinase CK2 complex","entity_type_key":"protein_complex"},"object":{"id":"695ab609-f122-5d5b-b4bb-7382a813aedf","slug":"slc39a7","display_name":"Human zinc transporter ZIP7 / SLC39A7","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"95b91869-d996-5739-af6c-3f69143a13c1","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-ck2-zip7-event","event_type":"biochemical_relationship","label":"A kinase can open the route from stored zinc to a cytoplasmic signal.","description":"The study identified CK2-dependent phosphorylation of ZIP7 as a regulatory step preceding cytosolic zinc release from intracellular stores.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6f10096-f415-5237-bca7-26d3234ee850","slug":"zip7-phosphorylation","display_name":"ZIP7 phosphorylation","entity_type_key":"cellular_process"},"role":"regulatory_event","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"transported_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4ceda93e-2b3b-5d47-8eea-34ff2c531518","slug":"ck2","display_name":"Human protein kinase CK2 complex","entity_type_key":"protein_complex"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"695ab609-f122-5d5b-b4bb-7382a813aedf","slug":"slc39a7","display_name":"Human zinc transporter ZIP7 / SLC39A7","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"ZIP7 phosphorylation (regulatory_event); Zinc(II) ion (transported_ion)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-signaling-sources/22317921-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"a8e31db38c22019d7ebef8ff165e2b3dc0b3a338e18514f0bf0c48cc5215944d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human breast-cell model with ZIP7/CK2 perturbations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Signaling stimuli and ZIP7/CK2 phosphorylation comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cellular signaling study; it does not establish dietary zinc supplementation as an anticancer intervention. Intracellular release is different from net dietary uptake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A kinase can open the route from stored zinc to a cytoplasmic signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-sig-22317921] Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. (2012). https://pubmed.ncbi.nlm.nih.gov/22317921/ DOI: 10.1126/scisignal.2002585","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Endoplasmic reticulum and cytoplasm","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e2ec771d-f4f9-5261-a648-2d5e613c261c","evidence_kind":"source_excerpt","locator":"Lines 985-997","start_line":985,"end_line":997,"excerpt":"### zn-sig-ck2-zip7\nThe study identified CK2-dependent phosphorylation of ZIP7 as a regulatory step preceding cytosolic zinc release from intracellular stores.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A kinase can open the route from stored zinc to a cytoplasmic signal.\norganism: Homo sapiens\ntissue_or_cell_type: Endoplasmic reticulum and cytoplasm\nexperimental_model: Human breast-cell model with ZIP7/CK2 perturbations\nlimitations: Cellular signaling study; it does not establish dietary zinc supplementation as an anticancer intervention. Intracellular release is different from net dietary uptake.\nexposure: Signaling stimuli and ZIP7/CK2 phosphorylation comparisons.\ncross_nutrient: ZIP7 phosphorylation (regulatory_event); Zinc(II) ion (transported_ion)\nevidence_span: {\"source_cache\": \"artifacts/zinc-signaling-sources/22317921-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"a8e31db38c22019d7ebef8ff165e2b3dc0b3a338e18514f0bf0c48cc5215944d\"}\n[zn-sig-22317921] Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. (2012). https://pubmed.ncbi.nlm.nih.gov/22317921/ DOI: 10.1126/scisignal.2002585","model_system":"Human breast-cell model with ZIP7/CK2 perturbations","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-sig-22317921] Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. (2012). https://pubmed.ncbi.nlm.nih.gov/22317921/ DOI: 10.1126/scisignal.2002585","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}