{"id":"593aa824-eaa4-58de-b1d4-d35046111b5c","stable_key":"a2968a2f-5b00-5212-8b8c-8a4262bcb149:atra-induces-tet2-transcription","predicate":"increases_transcript_expression_of","statement":"All-trans retinoic acid induced retinoic-acid-receptor-alpha-mediated TET2 transcription in myeloid leukaemia cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"653fbb9f-a66b-5708-9070-00a359e91ba9","mechanism_event_label":"All-trans retinoic acid induced retinoic-acid-receptor-alpha-mediated TET2 transcription in myeloid leukaemia cells.","subject":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"object":{"id":"5433ea92-f679-5b25-a872-cb8a636ae4e1","slug":"tet2-human","display_name":"Human 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models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"All-trans retinoic acid","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A transcript rise is not a measured rise in enzyme activity, and pharmacological ATRA is not dietary vitamin A.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Retinoic acid made leukaemia cells produce more of the TET2 enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[celrep-2025] Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation (2025). https://pubmed.ncbi.nlm.nih.gov/41037397/ DOI: 10.1016/j.celrep.2025.116379","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Myeloid leukaemia cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"57080d07-e248-5ff5-9566-b88ac5841400","evidence_kind":"source_excerpt","locator":"Lines 143-151","start_line":143,"end_line":151,"excerpt":"## atra-induces-tet2-transcription\nAll-trans retinoic acid induced retinoic-acid-receptor-alpha-mediated TET2 transcription in myeloid leukaemia cells.\nModel/species: Myeloid leukaemia cell lines and primary human AML models\nOrganism: Homo sapiens\nTissue/system: Myeloid leukaemia cells\nExposure: All-trans retinoic acid\nDuration: Culture treatment\nLimits: A transcript rise is not a measured rise in enzyme activity, and pharmacological ATRA is not dietary vitamin A.\nPrimary reference: [celrep-2025] Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation (2025). https://pubmed.ncbi.nlm.nih.gov/41037397/ DOI: 10.1016/j.celrep.2025.116379","model_system":"Myeloid leukaemia cell lines and primary human AML models","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c0b9b176-985b-55c7-b8f5-f3ca16a7ddfe","stable_key":"import-a2968a2f-5b00-5212-8b8c-8a4262bcb149","title":"TET2 loss and malignancy: the step between a nutrient-responsive enzyme and the disease (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies located by Europe PMC title search, with every statement drafted from the retrieved abstract. Two pairs share a laboratory and are recorded as one line of evidence each. Genetic loss of function, pharmacological exposure and dietary depletion are kept as separate record types. Not publisher full text.","file_path":"","sha256":"22e2c8388d4f0c1813546ba6a9ccee3fa14c0c8f578bd9bd80103c1390b2536b","revision_id":"fbc29d8d-0420-562c-bfdb-1b5af42f2d08","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}