{"id":"58f07aa5-d5e3-557b-a036-d7aef4bb7732","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-eef1a","predicate":"mediates_egcg_response_through","statement":"A genetic screen identified eEF1A as a component of 67LR-dependent EGCG signaling.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9c68a040-0c14-582c-82be-b45ee709fd0e","mechanism_event_label":"The surface signal depends on an intracellular relay.","subject":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"object":{"id":"fd0edc10-cd26-5e13-af04-a8ab865108a4","slug":"eef1a-family","display_name":"Eukaryotic elongation factor 1A family","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"9c68a040-0c14-582c-82be-b45ee709fd0e","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-eef1a-event","event_type":"observed_relationship","label":"The surface signal depends on an intracellular relay.","description":"A genetic screen identified eEF1A as a component of 67LR-dependent EGCG signaling.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fd0edc10-cd26-5e13-af04-a8ab865108a4","slug":"eef1a-family","display_name":"Eukaryotic elongation factor 1A family","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Genetic screen, cell signaling and experimental tumor-growth models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pathway dependency in these models does not establish human cancer treatment or a dietary threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The surface signal depends on an intracellular relay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18079119/ · DOI 10.1074/jbc.m707892200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e131f9e2-3033-5753-9549-0761d531bc03","evidence_kind":"source_excerpt","locator":"Lines 28-34","start_line":28,"end_line":34,"excerpt":"## egcg-eef1a\nThe surface signal depends on an intracellular relay.\nA genetic screen identified eEF1A as a component of 67LR-dependent EGCG signaling.\nModel: Genetic screen, cell signaling and experimental tumor-growth models.\nLimitations: Pathway dependency in these models does not establish human cancer treatment or a dietary threshold.\nEvidence access: primary abstract.\nGreen tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18079119/ · DOI 10.1074/jbc.m707892200","model_system":"Genetic screen, cell signaling and experimental tumor-growth models.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}