{"id":"58b28ef2-80e3-51d5-8cd0-ddda69575b25","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-acute-leptin","predicate":"similar_response_to_sucrose","statement":"HFCS and sucrose produced similar 24-hour circulating leptin profiles in the crossover study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"9b210e67-9d0b-5427-b4c3-00b1d68ed722","mechanism_event_label":"HFCS and sucrose produced similar 24-hour circulating leptin profiles in the crossover study.","subject":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"object":{"id":"17a76361-15de-5b83-8168-f36f8cc8cc3d","slug":"leptin","display_name":"LEP","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"9b210e67-9d0b-5427-b4c3-00b1d68ed722","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-acute-leptin-event","event_type":"observed_relationship","label":"HFCS and sucrose produced similar 24-hour circulating leptin profiles in the crossover study.","description":"HFCS and sucrose produced similar 24-hour circulating leptin profiles in the crossover study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"17a76361-15de-5b83-8168-f36f8cc8cc3d","slug":"leptin","display_name":"LEP","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"832b1926-18e7-5b76-8dc4-bad8ed234645","slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"HFCS or sucrose beverages with 3 isocaloric meals; exact sugar allocation not recovered from primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"24-hour profiles","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"34 adults in crossover meal study; 8 men also received pure monosaccharides","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Direct HFCS versus sucrose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short feeding study; eight-man fructose/glucose comparison is a subset and does not establish long-term equivalence or appetite control.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"34 adults in crossover meal study; 8 men also received pure monosaccharides","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"HFCS and sucrose produced similar 24-hour circulating leptin profiles in the crossover study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. (2008). https://pubmed.ncbi.nlm.nih.gov/18469239/ DOI: 10.1093/ajcn/87.5.1194","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral beverages with meals","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"24-hour endocrine and triglyceride profiles","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cbbee3ff-3a2d-500f-a6da-5b3333ee06ba","evidence_kind":"source_excerpt","locator":"Lines 365-375","start_line":365,"end_line":375,"excerpt":"## hfcs-acute-leptin\nHFCS and sucrose produced similar 24-hour circulating leptin profiles in the crossover study.\nModel/species: 34 adults in crossover meal study; 8 men also received pure monosaccharides\nTissue: 24-hour endocrine and triglyceride profiles\nExposure: HFCS or sucrose beverages with 3 isocaloric meals; exact sugar allocation not recovered from primary abstract\nRoute: Oral beverages with meals\nDuration: 24-hour profiles\nExposure scope: Direct HFCS versus sucrose\nLimits: Short feeding study; eight-man fructose/glucose comparison is a subset and does not establish long-term equivalence or appetite control.\nReference: Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. (2008). https://pubmed.ncbi.nlm.nih.gov/18469239/ DOI: 10.1093/ajcn/87.5.1194\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"34 adults in crossover meal study; 8 men also received pure monosaccharides","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}