{"id":"587c8937-66cc-59fa-99da-a83dbd4488ac","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:mevalonate-supplies-isoprenoids","predicate":"supplies","statement":"The mevalonate pathway produces isoprenoids required for functions ranging from cholesterol synthesis to growth control, under feedback regulation that also governs low-density-lipoprotein receptors.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0f425ea8-2615-5c68-949b-83f029e9ee3f","mechanism_event_label":"The mevalonate pathway produces isoprenoids required for functions ranging from cholesterol synthesis to growth control, under feedback regulation that also governs low-density-lipoprotein receptors.","subject":{"id":"3df322fd-ac21-5bd1-aa46-4af1ec708b57","slug":"mevalonate","display_name":"Mevalonate","entity_type_key":"small_molecule"},"object":{"id":"7e6d85c1-25b7-549b-9883-8e9d5d11ae3d","slug":"geranylgeranyl-diphosphate","display_name":"Geranylgeranyl diphosphate / GGPP","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"0f425ea8-2615-5c68-949b-83f029e9ee3f","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:mevalonate-supplies-isoprenoids-event","event_type":"observed_relationship","label":"The mevalonate pathway produces isoprenoids required for functions ranging from cholesterol synthesis to growth control, under feedback regulation that also governs low-density-lipoprotein receptors.","description":"The mevalonate pathway produces isoprenoids required for functions ranging from cholesterol synthesis to growth control, under feedback regulation that also governs low-density-lipoprotein receptors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3df322fd-ac21-5bd1-aa46-4af1ec708b57","slug":"mevalonate","display_name":"Mevalonate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7e6d85c1-25b7-549b-9883-8e9d5d11ae3d","slug":"geranylgeranyl-diphosphate","display_name":"Geranylgeranyl diphosphate / GGPP","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9ccdf853-7005-5a53-b053-83574a870ad7","slug":"farnesyl-diphosphate","display_name":"Farnesyl diphosphate / FPP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a8b5e5e1-b5b5-551d-8fd4-72f7b45de78a","slug":"hmgcr","display_name":"HMG-CoA reductase (HMGCR)","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Review of mammalian mevalonate-pathway regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Not applicable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A review of regulatory architecture, not a measurement of any one statin's effect on any one isoprenoid pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Review of mammalian mevalonate-pathway regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The mevalonate pathway produces isoprenoids required for functions ranging from cholesterol synthesis to growth control, under feedback regulation that also governs low-density-lipoprotein receptors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Regulation of the mevalonate pathway. (1990). https://pubmed.ncbi.nlm.nih.gov/1967820/ DOI: 10.1038/343425a0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Not applicable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Isoprenoid and sterol end-products","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"36085793-74bb-5758-bc4d-4306d302a35d","evidence_kind":"source_excerpt","locator":"Lines 24-32","start_line":24,"end_line":32,"excerpt":"## mevalonate-supplies-isoprenoids\nThe mevalonate pathway produces isoprenoids required for functions ranging from cholesterol synthesis to growth control, under feedback regulation that also governs low-density-lipoprotein receptors.\nModel/species: Review of mammalian mevalonate-pathway regulation\nTissue/system: Isoprenoid and sterol end-products\nExposure: Not applicable\nRoute: Not applicable\nLimits: A review of regulatory architecture, not a measurement of any one statin's effect on any one isoprenoid pool.\nPrimary reference: Regulation of the mevalonate pathway. (1990). https://pubmed.ncbi.nlm.nih.gov/1967820/ DOI: 10.1038/343425a0\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"a4431d8c-34d7-5db7-9edf-a35f68feba39","stable_key":"import-1fb6218a-60d1-55ea-87fe-07d15d0fc46f","title":"Atorvastatin: mechanism of action from target occupancy to isoprenoids, transport, muscle and metabolism (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Findings obtained with mevastatin, simvastatin or the statin class are recorded against those subjects. Study-specific citations, doses, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"6307f1acf99f90662320328974781ee660348754257b1e1555701ad597edc8e5","revision_id":"447c5978-ba3f-58fe-ac85-664caa72e01b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}