{"id":"574a75b7-35c5-5b94-a834-4b4b78d94659","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-lycopene-auc","predicate":"reduces","statement":"Lycopene AUC was reduced with the tested fibers, including pectin; the multi-fiber effect range is not a pectin-specific number.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"698eaa2c-b301-56c4-894c-90ef405b3a6d","mechanism_event_label":"Pectin was associated with a smaller lycopene response.","subject":{"id":"5449346d-7614-5c4b-bbd2-03fb4dd71aeb","slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"},"object":{"id":"f8c533ff-ee12-5949-a269-f749566b25f0","slug":"postmeal-lycopene-response","display_name":"Human post-meal plasma lycopene response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"698eaa2c-b301-56c4-894c-90ef405b3a6d","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-lycopene-auc-event","event_type":"observed_intervention","label":"Pectin was associated with a smaller lycopene response.","description":"Lycopene AUC was reduced with the tested fibers, including pectin; the multi-fiber effect range is not a pectin-specific number.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"measured_substance","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5449346d-7614-5c4b-bbd2-03fb4dd71aeb","slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f8c533ff-ee12-5949-a269-f749566b25f0","slug":"postmeal-lycopene-response","display_name":"Human post-meal plasma lycopene response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/10573545.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\", \"start_char\": 0, \"end_char\": 1340, \"text_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Crossover mixed-carotenoid meal study in six healthy women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Pectin or other fibers at 0.15 g/kg with a carotenoid and alpha-tocopherol mixture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reported effect-size ranges cover multiple fibers, not one pectin-specific estimate. Plasma exposure does not establish long-term deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pectin was associated with a smaller lycopene response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p10573545] Some dietary fibers reduce the absorption of carotenoids in women. (1999). https://pubmed.ncbi.nlm.nih.gov/10573545/ DOI: 10.1093/jn/129.12.2170","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma 24-hour area under the curve","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"200ee7c2-9fd2-5d68-a33f-1f87df9b0763","evidence_kind":"source_excerpt","locator":"Lines 685-696","start_line":685,"end_line":696,"excerpt":"### pectin-lycopene-auc\nLycopene AUC was reduced with the tested fibers, including pectin; the multi-fiber effect range is not a pectin-specific number.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Pectin was associated with a smaller lycopene response.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma 24-hour area under the curve\nexperimental_model: Crossover mixed-carotenoid meal study in six healthy women\nlimitations: Reported effect-size ranges cover multiple fibers, not one pectin-specific estimate. Plasma exposure does not establish long-term deficiency.\nexposure: Pectin or other fibers at 0.15 g/kg with a carotenoid and alpha-tocopherol mixture\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/10573545.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\", \"start_char\": 0, \"end_char\": 1340, \"text_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\"}\n[pectin-p10573545] Some dietary fibers reduce the absorption of carotenoids in women. (1999). https://pubmed.ncbi.nlm.nih.gov/10573545/ DOI: 10.1093/jn/129.12.2170","model_system":"Crossover mixed-carotenoid meal study in six healthy women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pectin-p10573545] Some dietary fibers reduce the absorption of carotenoids in women. (1999). https://pubmed.ncbi.nlm.nih.gov/10573545/ DOI: 10.1093/jn/129.12.2170","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"13c3aae7-702f-5bc9-9fca-a57d141882ce","stable_key":"import-d17caac5-7018-5ca8-9e96-95afeb384bc4","title":"Pectin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff07001bc37d008a1e23fbba37146d0b0d33cc8c0bf42a75f1e1a7ef0aaeb489","revision_id":"76f1a2c5-02d0-511b-bde5-33079d7af6a0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}