{"id":"573fa2b4-c34e-5545-9286-7ee973ebb7d9","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-etfdh-muscle-loss","predicate":"loss_impairs","statement":"Muscle-specific Etfdh deletion caused complex III dysfunction and myopathy in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dad87cb9-75d9-5539-b140-30f5d989d2b1","mechanism_event_label":"A defect upstream can disturb the system that recycles the shared electron carrier.","subject":{"id":"e366d6d7-69c0-5cb1-89b2-7db3703b6226","slug":"mouse-etfdh","display_name":"Mouse electron transfer flavoprotein dehydrogenase / Etfdh","entity_type_key":"protein"},"object":{"id":"3b73f316-a551-517d-82b8-6af922d5a091","slug":"respiratory-complex-iii","display_name":"Mitochondrial respiratory complex III","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"dad87cb9-75d9-5539-b140-30f5d989d2b1","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-etfdh-muscle-loss-event","event_type":"biochemical_relationship","label":"A defect upstream can disturb the system that recycles the shared electron carrier.","description":"Muscle-specific Etfdh deletion caused complex III dysfunction and myopathy in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e366d6d7-69c0-5cb1-89b2-7db3703b6226","slug":"mouse-etfdh","display_name":"Mouse electron transfer flavoprotein dehydrogenase / Etfdh","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3b73f316-a551-517d-82b8-6af922d5a091","slug":"respiratory-complex-iii","display_name":"Mitochondrial respiratory complex III","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/38243131.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"de9afaeca8a144d79c9f0d0d3b3faafaa4560af2292b8624d1a04ed45ee5d136\", \"start_char\": 0, \"end_char\": 1039, \"text_sha256\": \"de9afaeca8a144d79c9f0d0d3b3faafaa4560af2292b8624d1a04ed45ee5d136\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Muscle-specific knockout and protein-complex analyses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Etfdh deletion and metabolon characterization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Skeletal-muscle context; does not establish identical complex organization in every human tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mouse skeletal muscle and biochemical systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A defect upstream can disturb the system that recycles the shared electron carrier.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p38243131] An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis. 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