{"id":"570eb84c-2a7a-5eb9-b2f2-2131dcdf4614","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-salts-potassium-not-rescued-by-alkali","predicate":"salt_loading_increases","statement":"All three potassium salts increased plasma potassium despite their different acid-base effects.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2a7d49f0-0d0f-56ff-a90b-3bd981120f98","mechanism_event_label":"An alkalizing potassium salt did not remove the potassium rise in this study.","subject":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"object":{"id":"bb23d568-e85f-5bdd-b264-92d73b8dce53","slug":"plasma-potassium-concentration","display_name":"Plasma potassium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2a7d49f0-0d0f-56ff-a90b-3bd981120f98","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-salts-potassium-not-rescued-by-alkali-event","event_type":"observed_intervention","label":"An alkalizing potassium salt did not remove the potassium rise in this study.","description":"All three potassium salts increased plasma potassium despite their different acid-base effects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"role":"tested_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5de32c9c-ee6a-506f-8e94-efd1698f434e","slug":"potassium-bicarbonate","display_name":"Potassium bicarbonate","entity_type_key":"chemical_species"},"role":"tested_form","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7e4ef8bd-e840-515a-8bfe-6fdee0ef5b8c","slug":"potassium-gluconate","display_name":"Potassium gluconate","entity_type_key":"chemical_species"},"role":"tested_form","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"bb23d568-e85f-5bdd-b264-92d73b8dce53","slug":"plasma-potassium-concentration","display_name":"Plasma potassium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Same CKD crossover.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cannot infer long-term food effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An alkalizing potassium salt did not remove the potassium rise in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-ckd-salts2026] Randomized Cross-Over Trial of Electrolyte, Acid-Base and Blood Pressure Effects of Salt Supplements in CKD (2026). https://pubmed.ncbi.nlm.nih.gov/42381762/ DOI: 10.1016/j.ekir.2026.106619","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d9923e2a-71a7-52cc-b154-ffaae06f7fd2","evidence_kind":"source_excerpt","locator":"Lines 1674-1683","start_line":1674,"end_line":1683,"excerpt":"### k-ckd-salts-potassium-not-rescued-by-alkali\nAll three potassium salts increased plasma potassium despite their different acid-base effects.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An alkalizing potassium salt did not remove the potassium rise in this study.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Same CKD crossover.\nlimitations: Cannot infer long-term food effects.\n[k-ckd-salts2026] Randomized Cross-Over Trial of Electrolyte, Acid-Base and Blood Pressure Effects of Salt Supplements in CKD (2026). https://pubmed.ncbi.nlm.nih.gov/42381762/ DOI: 10.1016/j.ekir.2026.106619","model_system":"Same CKD crossover.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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