{"id":"5704e961-e38a-53fa-8ba4-95d0dd46916f","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-coffee-water","predicate":"no_detected_difference","statement":"In 50 habitual male coffee drinkers, coffee and water produced no significant difference in total body water or 24-hour urine volume.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"6c1cd08c-2a14-5c8f-bcec-d6311f195486","mechanism_event_label":"An acute diuretic effect does not mean habitual coffee drinking always dehydrates.","subject":{"id":"5c296d2a-5e73-5f07-912a-9e9b0894fcd1","slug":"coffee-beverage","display_name":"Coffee beverage, study-specific mixture","entity_type_key":"chemical_species"},"object":{"id":"7c5b5de4-8e41-5bce-9f14-ed7c10d56459","slug":"total-body-water","display_name":"Total body water","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6c1cd08c-2a14-5c8f-bcec-d6311f195486","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-coffee-water-event","event_type":"observed_relationship","label":"An acute diuretic effect does not mean habitual coffee drinking always dehydrates.","description":"In 50 habitual male coffee drinkers, coffee and water produced no significant difference in total body water or 24-hour urine volume.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5c296d2a-5e73-5f07-912a-9e9b0894fcd1","slug":"coffee-beverage","display_name":"Coffee beverage, study-specific mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7c5b5de4-8e41-5bce-9f14-ed7c10d56459","slug":"total-body-water","display_name":"Total body water","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2f98661c-f583-5753-969d-75e708ff8dc6","slug":"renal-water-excretion","display_name":"Renal water excretion","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-day crossover; four 200 mL servings supplying 4 mg/kg/day caffeine versus equal water.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole coffee plus fluid in habituated men, not dry caffeine or an acute bolus in nonusers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An acute diuretic effect does not mean habitual coffee drinking always dehydrates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24416202/ · DOI 10.1371/journal.pone.0084154","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"14fe6215-de19-5c1b-8f5b-6441b6368c88","evidence_kind":"source_excerpt","locator":"Lines 372-378","start_line":372,"end_line":378,"excerpt":"## caf-coffee-water\nAn acute diuretic effect does not mean habitual coffee drinking always dehydrates.\nIn 50 habitual male coffee drinkers, coffee and water produced no significant difference in total body water or 24-hour urine volume.\nModel: Three-day crossover; four 200 mL servings supplying 4 mg/kg/day caffeine versus equal water.\nLimitations: Whole coffee plus fluid in habituated men, not dry caffeine or an acute bolus in nonusers.\nEvidence access: Primary abstract\nNo evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24416202/ · DOI 10.1371/journal.pone.0084154","model_system":"Three-day crossover; four 200 mL servings supplying 4 mg/kg/day caffeine versus equal water.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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