{"id":"56ce1e1e-2087-5c77-862c-b9f10945acdc","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-sympathetic-attribution","predicate":"mediates","statement":"The authors concluded that physiological changes induced by water immersion are mediated by humoral control mechanisms, while responses induced by cold are mainly due to increased activity of the sympathetic nervous system, with no correlation between changes in rectal temperature and changes in hormone production.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ddf6c755-2474-5bea-a8e6-b69b628f126b","mechanism_event_label":"The water effects and the cold effects travel by two different routes.","subject":{"id":"e24f7882-41c6-5080-945c-a4d7ff1712ba","slug":"sympathetic-nervous-activity","display_name":"Sympathetic nervous system activity","entity_type_key":"cellular_process"},"object":{"id":"f852c25a-227b-571c-9f86-257dd9c90113","slug":"metabolic-rate","display_name":"Whole-body metabolic rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ddf6c755-2474-5bea-a8e6-b69b628f126b","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-sympathetic-attribution-event","event_type":"observed_intervention","label":"The water effects and the cold effects travel by two different routes.","description":"The authors concluded that physiological changes induced by water immersion are mediated by humoral control mechanisms, while responses induced by cold are mainly due to increased activity of the sympathetic nervous system, with no correlation between changes in rectal temperature and changes in hormone production.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e24f7882-41c6-5080-945c-a4d7ff1712ba","slug":"sympathetic-nervous-activity","display_name":"Sympathetic nervous system activity","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f852c25a-227b-571c-9f86-257dd9c90113","slug":"metabolic-rate","display_name":"Whole-body metabolic rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/10751106.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\", \"start_char\": 0, \"end_char\": 2332, \"text_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One hour head-out immersion at three water temperatures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The thermoneutral arm separates hydrostatic pressure from cold. 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Cortisol did not rise at any temperature, which bears directly on calling immersion a stress response.\nexposure: One hour head-out immersion at three water temperatures\nevidence_span: {\"source_cache\": \"artifacts/cold-research/10751106.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\", \"start_char\": 0, \"end_char\": 2332, \"text_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\"}\n[cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","model_system":"Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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