{"id":"56b766df-c049-51eb-b7a2-556368c2bf84","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-depletion-gsk3","predicate":"depletion_activates","statement":"Lithium depletion increased GSK3beta expression and activation-associated signals in mouse brain.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"366cc161-8c73-5939-b511-11de11f451c4","mechanism_event_label":"The enzyme connects availability to downstream responses.","subject":{"id":"fb76d6c2-e8a0-5c22-8ebb-f06e4c66d50c","slug":"mouse-cortical-lithium-availability","display_name":"Mouse cortical lithium availability","entity_type_key":"cellular_process"},"object":{"id":"e7b85cc5-eead-5551-ba6d-40420edd8156","slug":"mouse-gsk3b","display_name":"Mouse glycogen synthase kinase 3 beta / Gsk3b","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"366cc161-8c73-5939-b511-11de11f451c4","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-depletion-gsk3-event","event_type":"observed_relationship","label":"The enzyme connects availability to downstream responses.","description":"Lithium depletion increased GSK3beta expression and activation-associated signals in mouse brain.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fb76d6c2-e8a0-5c22-8ebb-f06e4c66d50c","slug":"mouse-cortical-lithium-availability","display_name":"Mouse cortical lithium availability","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e7b85cc5-eead-5551-ba6d-40420edd8156","slug":"mouse-gsk3b","display_name":"Mouse glycogen synthase kinase 3 beta / Gsk3b","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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