{"id":"566db22b-4337-5dec-93f6-3bca00c7f858","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-winter-swimmer-threshold","predicate":"reduces","statement":"In winter swimmers the thermoregulatory threshold for inducing cold thermogenesis was lowered by 0.34 degrees C while apparent hypothalamic thermosensitivity was unchanged, and the magnitude of cold thermogenesis related solely to rectal temperature, indicating predominance of central temperature input.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"3a4f1396-c79f-55c7-b824-1aa48747a836","mechanism_event_label":"Repeated exposure moves the set point at which the body decides to make heat.","subject":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"object":{"id":"0d4d46c7-183f-54e2-a8d9-f7b4f2d46145","slug":"thermoregulatory-threshold","display_name":"Thermoregulatory threshold for inducing cold thermogenesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3a4f1396-c79f-55c7-b824-1aa48747a836","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-winter-swimmer-threshold-event","event_type":"observed_intervention","label":"Repeated exposure moves the set point at which the body decides to make heat.","description":"In winter swimmers the thermoregulatory threshold for inducing cold thermogenesis was lowered by 0.34 degrees C while apparent hypothalamic thermosensitivity was unchanged, and the magnitude of cold thermogenesis related solely to rectal temperature, indicating predominance of central temperature input.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1453ba57-6d19-5f7d-972c-afedf2b9b39a","slug":"hypothalamic-thermosensitivity","display_name":"Apparent hypothalamic thermosensitivity","entity_type_key":"cellular_process"},"role":"unchanged_property","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d7989a0-37d9-5c72-84bb-29d7d4a5a932","slug":"core-temperature","display_name":"Core (rectal) body temperature","entity_type_key":"cellular_process"},"role":"controlling_input","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0d4d46c7-183f-54e2-a8d9-f7b4f2d46145","slug":"thermoregulatory-threshold","display_name":"Thermoregulatory threshold for inducing cold thermogenesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/10825419.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62\", \"start_char\": 0, \"end_char\": 2308, \"text_sha256\": \"df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cold-adapted winter swimmers and controls during one hour of immersion at 13 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One hour of cold water immersion at 13 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A comparison of adapted and unadapted people. The adrenaline contribution to thermogenesis is the authors’ estimate from their thermoregulation data, not a direct measurement of a hormone-driven heat fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Repeated exposure moves the set point at which the body decides to make heat.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p10825419] Thermoregulation in winter swimmers and physiological significance of human catecholamine thermogenesis. 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The adrenaline contribution to thermogenesis is the authors’ estimate from their thermoregulation data, not a direct measurement of a hormone-driven heat fraction.\nexposure: One hour of cold water immersion at 13 degrees C\nevidence_span: {\"source_cache\": \"artifacts/cold-research/10825419.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62\", \"start_char\": 0, \"end_char\": 2308, \"text_sha256\": \"df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62\"}\n[cold-p10825419] Thermoregulation in winter swimmers and physiological significance of human catecholamine thermogenesis. 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