{"id":"55e5769c-e128-5b20-b8bf-f1ae9468b97a","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-diabetes-thiamine-albuminuria","predicate":"reduces_in_pilot","statement":"In the 40-person pilot, urinary albumin excretion was lower after three months of thiamine than placebo; glycemic control, lipids and blood pressure did not change significantly.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0c2f5d55-434d-5daa-b815-b7a6f0b42ca1","mechanism_event_label":"A small trial suggested a renal biomarker benefit without showing its molecular cause.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"c12568d8-842f-5325-b458-c562a0ed8126","slug":"urinary-albumin-excretion","display_name":"Urinary albumin excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0c2f5d55-434d-5daa-b815-b7a6f0b42ca1","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-diabetes-thiamine-albuminuria-event","event_type":"observed_intervention","label":"A small trial suggested a renal biomarker benefit without showing its molecular cause.","description":"In the 40-person pilot, urinary albumin excretion was lower after three months of thiamine than placebo; glycemic control, lipids and blood pressure did not change significantly.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c12568d8-842f-5325-b458-c562a0ed8126","slug":"urinary-albumin-excretion","display_name":"Urinary albumin excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Type 2 diabetes with microalbuminuria.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Three 100 mg thiamine capsules daily versus placebo for three months, then two-month washout; study exposure only.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short trial; no long-term kidney-failure outcome and no isolated proof of transketolase mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A small trial suggested a renal biomarker benefit without showing its molecular cause.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-rabbani2009] High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study (2009). https://pubmed.ncbi.nlm.nih.gov/19057893/ DOI: 10.1007/s00125-008-1224-4","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"35bd943a-5220-5176-9158-eb9a64248e22","evidence_kind":"source_excerpt","locator":"Lines 1843-1853","start_line":1843,"end_line":1853,"excerpt":"### b1-diabetes-thiamine-albuminuria\nIn the 40-person pilot, urinary albumin excretion was lower after three months of thiamine than placebo; glycemic control, lipids and blood pressure did not change significantly.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A small trial suggested a renal biomarker benefit without showing its molecular cause.\norganism: Homo sapiens\ntissue_or_cell_type: Urine\nexperimental_model: Type 2 diabetes with microalbuminuria.\nlimitations: Small short trial; no long-term kidney-failure outcome and no isolated proof of transketolase mediation.\nexposure: Three 100 mg thiamine capsules daily versus placebo for three months, then two-month washout; study exposure only.\n[b1-rabbani2009] High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study (2009). https://pubmed.ncbi.nlm.nih.gov/19057893/ DOI: 10.1007/s00125-008-1224-4","model_system":"Type 2 diabetes with microalbuminuria.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-rabbani2009] High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study (2009). https://pubmed.ncbi.nlm.nih.gov/19057893/ DOI: 10.1007/s00125-008-1224-4","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}