{"id":"55ba1e15-042a-5efe-adef-374ab4f72d03","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-transport","predicate":"undergoes_transport","statement":"Airway epithelia transported iodide with apparent Km 111 ± 69 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a3dccf51-f2a9-5400-97a8-6098ad319ef7","mechanism_event_label":"Airway cells can transport iodide.","subject":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"object":{"id":"759b6f24-098d-5b19-b891-a5ad49fade50","slug":"cellular-iodide-uptake","display_name":"Cellular iodide uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a3dccf51-f2a9-5400-97a8-6098ad319ef7","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-transport-event","event_type":"observed_relationship","label":"Airway cells can transport iodide.","description":"Airway epithelia transported iodide with apparent Km 111 ± 69 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"759b6f24-098d-5b19-b891-a5ad49fade50","slug":"cellular-iodide-uptake","display_name":"Cellular iodide uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0d051c22-c0d2-5c22-91ad-4ee6894dc7a0","slug":"slc5a5","display_name":"Human sodium/iodide symporter / SLC5A5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed apical CFTR route was inferred pharmacologically, not proven by this experiment. This is iodide biology, not a KI-specific counter-ion effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Airway cells can transport iodide.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Transcellular thiocyanate transport by human airway epithelia. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15345749/ · DOI 10.1113/jphysiol.2004.071548","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7728ace6-6930-5257-a5f0-689e901d5997","evidence_kind":"source_excerpt","locator":"Lines 136-142","start_line":136,"end_line":142,"excerpt":"## ki-air-transport\nAirway cells can transport iodide.\nAirway epithelia transported iodide with apparent Km 111 ± 69 micromolar.\nModel: Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.\nLimitations: The proposed apical CFTR route was inferred pharmacologically, not proven by this experiment. This is iodide biology, not a KI-specific counter-ion effect.\nEvidence location: Primary abstract\nTranscellular thiocyanate transport by human airway epithelia. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15345749/ · DOI 10.1113/jphysiol.2004.071548","model_system":"Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}