{"id":"55297091-5e98-5a1b-b32d-27800067f679","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:wy14643-fao-rescue","predicate":"increases","statement":"WY14643 treatment restored fatty-acid-supported respiration in Dlat-overexpressing rat cardiomyocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9cc3b758-6555-551d-98c1-3ec5d1dc18a8","mechanism_event_label":"wy14643 fao rescue","subject":{"id":"b0839047-7117-5a14-8631-06f739bc4360","slug":"wy14643","display_name":"WY14643 experimental PPAR-alpha agonist","entity_type_key":"drug"},"object":{"id":"6314b700-44b5-5993-aa8f-a90e13a25f02","slug":"rat-cardiac-fao","display_name":"Rat cardiac fatty-acid oxidation capacity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9cc3b758-6555-551d-98c1-3ec5d1dc18a8","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:wy14643-fao-rescue","event_type":"increases","label":"wy14643 fao rescue","description":"Model-specific finding; read linked claim context and source-access tier.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b0839047-7117-5a14-8631-06f739bc4360","slug":"wy14643","display_name":"WY14643 experimental PPAR-alpha agonist","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6314b700-44b5-5993-aa8f-a90e13a25f02","slug":"rat-cardiac-fao","display_name":"Rat cardiac fatty-acid oxidation capacity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e8427370-8d01-5884-a98b-3fb441feffcd","slug":"rat-dlat-overexpression","display_name":"Dlat overexpression in neonatal rat ventricular cardiomyocytes","entity_type_key":"protein_state"},"role":"experimental background","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"full_text_and_supplement_review","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"compartment","value_text":"Mitochondria or cell lysate, depending on assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Adenovirus MOI 50:1 where applicable; compound concentrations not specified in reviewed methods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Adenovirus incubation 6–8 h; subsequent endpoint timing not consistently specified","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"rat-cardiac-fao","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Supplementary Figure S9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Adenoviral/cell perturbation study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"wy14643","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single primary study; not independently replicated here. Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. PPAR-alpha agonist experiment; dose and duration not specified in the reviewed text. 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Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. PPAR-alpha agonist experiment; dose and duration not specified in the reviewed text. It does not establish selective action on HADHA.\nprimary_locator: [{\"cache\": \"artifacts/dlat-curation/heart-blocks.json\", \"block_index\": 32, \"text_sha256\": \"ea1ec18a5210aa68822ce1416ae850de5ce871e100938a13a2c1dcc49c444731\", \"xml_element_id\": \"Par14\"}]\nplain_language: WY14643 treatment restored fatty-acid-supported respiration in Dlat-overexpressing rat cardiomyocytes.","model_system":"Adenoviral/cell perturbation study","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Quotation is the authored curation, not original publisher wording. Exact primary locators and access limits retained in contexts.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ee72956d-4fd4-58d3-9a94-e173bb1e3282","stable_key":"import-c156003d-8cdf-5259-8561-9803795ecc82","title":"DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence","document_type":"imported_text","citation_label":"AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation.","file_path":"","sha256":"159e5472c8b1d104625f9c648dc9ee24dcd5fe102109fd960bba50e9ba9de954","revision_id":"5ca6b1f1-fd75-5f8d-ba2b-0215fbf387c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}