{"id":"543fc0b6-0882-52a6-aafb-c95820012ead","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taurine-starvation-rna","predicate":"starvation_reduces","statement":"Taurine starvation reduced mitochondrial tRNA taurine modification in cultured cells, with corresponding dietary-depletion observations in cat liver and flatfish tissues.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3caa6877-8f26-5e1f-9903-7447efa9d145","mechanism_event_label":"Insufficient taurine can leave fewer tRNAs carrying the normal mark.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"dd968147-5f93-56d5-bc83-7fa01f9b0e42","slug":"mt-trna-taurinomethyluridine","display_name":"Mitochondrial tRNA 5-taurinomethyluridine / tau-m5U34","entity_type_key":"rna_modification"},"evidence_count":1,"mechanism_event":{"id":"3caa6877-8f26-5e1f-9903-7447efa9d145","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taurine-starvation-rna-event","event_type":"observed_relationship","label":"Insufficient taurine can leave fewer tRNAs carrying the normal mark.","description":"Taurine starvation reduced mitochondrial tRNA taurine modification in cultured cells, with corresponding dietary-depletion observations in cat liver and flatfish tissues.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dd968147-5f93-56d5-bc83-7fa01f9b0e42","slug":"mt-trna-taurinomethyluridine","display_name":"Mitochondrial tRNA 5-taurinomethyluridine / tau-m5U34","entity_type_key":"rna_modification"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e4ce9b58-a2a4-5ec2-a449-c529c360fb32","slug":"mto1","display_name":"Human mitochondrial tRNA modification protein / MTO1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"cd2a6b5d-a6cf-5829-b0e4-b52a0f92d153","slug":"gtpbp3","display_name":"Human mitochondrial GTP-binding protein 3 / GTPBP3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured-cell and dietary animal experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cats and flatfish differ from adult humans in endogenous taurine synthesis; no universal human plasma threshold was determined.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Insufficient taurine can leave fewer tRNAs carrying the normal mark.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29390138/ · DOI 10.1093/nar/gky068","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1093d610-a6d5-59ea-a36f-73b5e643b42e","evidence_kind":"source_excerpt","locator":"Lines 233-239","start_line":233,"end_line":239,"excerpt":"## taurine-taurine-starvation-rna\nInsufficient taurine can leave fewer tRNAs carrying the normal mark.\nTaurine starvation reduced mitochondrial tRNA taurine modification in cultured cells, with corresponding dietary-depletion observations in cat liver and flatfish tissues.\nModel: Cultured-cell and dietary animal experiments.\nLimitations: Cats and flatfish differ from adult humans in endogenous taurine synthesis; no universal human plasma threshold was determined.\nEvidence access: Primary abstract\nMetabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29390138/ · DOI 10.1093/nar/gky068","model_system":"Cultured-cell and dietary animal experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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