{"id":"52ed4d2f-877b-5c6b-8828-46c624a9ac8f","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-depletion-human-sodium-retention","predicate":"depletion_reduces","statement":"At fixed sodium intake, potassium depletion reduced urinary sodium from 110 to 83 mmol/day in this crossover.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"15e7d509-f59b-541f-b5f9-19e55e9489e3","mechanism_event_label":"A potassium shortage changed how the kidney handled sodium.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"fd3a60b1-8952-526a-b67b-10923acd61b1","slug":"urinary-sodium-excretion","display_name":"Urinary sodium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"15e7d509-f59b-541f-b5f9-19e55e9489e3","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-depletion-human-sodium-retention-event","event_type":"observed_intervention","label":"A potassium shortage changed how the kidney handled sodium.","description":"At fixed sodium intake, potassium depletion reduced urinary sodium from 110 to 83 mmol/day in this crossover.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"coaffected_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fd3a60b1-8952-526a-b67b-10923acd61b1","slug":"urinary-sodium-excretion","display_name":"Urinary sodium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"c2f562a3-c349-56f6-942c-2ba88c419217","evidence_kind":"source_excerpt","locator":"Lines 1509-1520","start_line":1509,"end_line":1520,"excerpt":"### k-depletion-human-sodium-retention\nAt fixed sodium intake, potassium depletion reduced urinary sodium from 110 to 83 mmol/day in this crossover.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A potassium shortage changed how the kidney handled sodium.\norganism: Homo sapiens\ntissue_or_cell_type: Kidney and urine\nexperimental_model: 12 hypertensive adults; ten-day periods.\nlimitations: Supports retention physiology; the human study did not measure the Kir4.1-WNK-NCC chain.\ncross_nutrient: Potassium -> sodium balance.\nexposure: 16 versus 96 mmol/day K; sodium 120 mmol/day.\n[k-krishna1991] Potassium depletion exacerbates essential hypertension (1991). https://pubmed.ncbi.nlm.nih.gov/2058867/ DOI: 10.7326/0003-4819-115-2-77","model_system":"12 hypertensive adults; ten-day periods.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-krishna1991] Potassium depletion exacerbates essential hypertension (1991). https://pubmed.ncbi.nlm.nih.gov/2058867/ DOI: 10.7326/0003-4819-115-2-77","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}