{"id":"52aad87b-89c3-5a93-9a61-e99a2bec7433","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-hexyl-glucosidase","predicate":"decreases_in_recorded_comparison","statement":"The synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6e95aa4c-39f0-528d-8861-d7a0a700fbb6","mechanism_event_label":"The synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.","subject":{"id":"6b776f18-63c2-5b64-b603-ddb6afb3749d","slug":"hexyl-rosmarinate","display_name":"Hexyl rosmarinate, synthetic ester","entity_type_key":"small_molecule"},"object":{"id":"0b0fb4b4-2330-5b88-a259-6bc598b25b29","slug":"ra-derivative-glucosidase-assay","display_name":"Alpha-glucosidase activity in the RA-derivative assay","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6e95aa4c-39f0-528d-8861-d7a0a700fbb6","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-hexyl-glucosidase-event","event_type":"experimental_observation","label":"The synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.","description":"### ra-hexyl-glucosidase\n\nThe synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.\nDo not attribute this derivative result to parent RA or human intestinal brush-border enzymes.\nModel and exposure: 2019 ester-derivative study; accessible abstract does not specify enzyme species.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Rosmarinic acid and its ester derivatives for enhancing antibacterial, α-glucosidase inhibitory, and lipid accumulation suppression activities. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31353663/ | https://doi.org/10.1111/jfbc.12719 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b776f18-63c2-5b64-b603-ddb6afb3749d","slug":"hexyl-rosmarinate","display_name":"Hexyl rosmarinate, synthetic ester","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"Hexyl rosmarinate","sequence_order":0,"notes":""},{"entity":{"id":"0b0fb4b4-2330-5b88-a259-6bc598b25b29","slug":"ra-derivative-glucosidase-assay","display_name":"Alpha-glucosidase activity in the RA-derivative assay","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"synthetic precursor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"assay comparator","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Hexyl rosmarinate\", \"comparator\": \"Luteolin comparator\", \"endpoint\": \"The synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"2019 ester-derivative study; accessible abstract does not specify enzyme species.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Rosmarinic acid and its ester derivatives for enhancing antibacterial, α-glucosidase inhibitory, and lipid accumulation suppression activities. | https://pubmed.ncbi.nlm.nih.gov/31353663/ | https://doi.org/10.1111/jfbc.12719","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-hexyl-glucosidase; Do not attribute this derivative result to parent RA or human intestinal brush-border enzymes.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"29173e1d-4f75-56d4-be96-8dd4b86eedfc","evidence_kind":"source_excerpt","locator":"Lines 538-544","start_line":538,"end_line":544,"excerpt":"### ra-hexyl-glucosidase\n\nThe synthetic hexyl RA ester inhibited alpha-glucosidase more strongly than the comparator luteolin in the reported assay.\nDo not attribute this derivative result to parent RA or human intestinal brush-border enzymes.\nModel and exposure: 2019 ester-derivative study; accessible abstract does not specify enzyme species.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Rosmarinic acid and its ester derivatives for enhancing antibacterial, α-glucosidase inhibitory, and lipid accumulation suppression activities. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31353663/ | https://doi.org/10.1111/jfbc.12719 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"2019 ester-derivative study; accessible abstract does not specify enzyme species.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}