{"id":"5279fdb9-cc7d-596c-a3b4-6abaf454030e","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-brain-loading","predicate":"increased","statement":"Mean brain total creatine increased 8.7%, with regional and individual variability, after four weeks of supplementation; changes were reversible on follow-up.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ffd97492-784e-550d-ada1-2b6373b32778","mechanism_event_label":"Brain stores rose modestly and unevenly, rather than matching the much larger changes sometimes seen in muscle.","subject":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"object":{"id":"c6071833-4355-5a87-9123-8cc3d12c9bb4","slug":"brain-total-creatine","display_name":"Brain total creatine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ffd97492-784e-550d-ada1-2b6373b32778","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-brain-loading-event","event_type":"observed_intervention","label":"Brain stores rose modestly and unevenly, rather than matching the much larger changes sometimes seen in muscle.","description":"Mean brain total creatine increased 8.7%, with regional and individual variability, after four weeks of supplementation; changes were reversible on follow-up.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c6071833-4355-5a87-9123-8cc3d12c9bb4","slug":"brain-total-creatine","display_name":"Brain total creatine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/10484486.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"91190f8691b1728904ae6d8a46b65c2c731b75fe9fe876d964e18facc61c7c9d\", \"start_char\": 0, \"end_char\": 1490, \"text_sha256\": \"91190f8691b1728904ae6d8a46b65c2c731b75fe9fe876d964e18facc61c7c9d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Before/after quantitative proton MRS with washout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"20 g/day creatine monohydrate for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small non-placebo-controlled study; total creatine includes the creatine/phosphocreatine signal and is not a direct cognition endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Six healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Brain stores rose modestly and unevenly, rather than matching the much larger changes sometimes seen in muscle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p10484486] Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. 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