{"id":"5265aba4-5f70-556e-acca-86e8149fff88","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-sweat-reabsorption","predicate":"reduced_permeability_impairs","statement":"CF sweat ducts showed low chloride permeability and impaired NaCl reabsorption.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"66327497-4c3f-59fe-bb60-641c10ab321d","mechanism_event_label":"A salty sweat measurement can reflect failure to reclaim salt, not excessive intake.","subject":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"object":{"id":"a975dc32-120e-525b-a89d-23608d304eb7","slug":"sweat-salt-reabsorption","display_name":"Sweat-duct sodium chloride reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"66327497-4c3f-59fe-bb60-641c10ab321d","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-sweat-reabsorption-event","event_type":"biochemical_relationship","label":"A salty sweat measurement can reflect failure to reclaim salt, not excessive intake.","description":"CF sweat ducts showed low chloride permeability and impaired NaCl reabsorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"co_reabsorbed_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a975dc32-120e-525b-a89d-23608d304eb7","slug":"sweat-salt-reabsorption","display_name":"Sweat-duct sodium chloride reabsorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/6823316.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8ce2ab2d15d30590a4e4d13e12060fc8656238cea8856a2aad03ed9e2e4dcee4\", \"start_char\": 0, \"end_char\": 642, \"text_sha256\": \"8ce2ab2d15d30590a4e4d13e12060fc8656238cea8856a2aad03ed9e2e4dcee4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Microperfusion of isolated sweat ducts","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cystic fibrosis versus control","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Predates molecular CFTR identification; does not equate sweat chloride with blood chloride.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human controls and cystic fibrosis patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A salty sweat measurement can reflect failure to reclaim salt, not excessive intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p6823316] Chloride impermeability in cystic fibrosis. (1983). https://pubmed.ncbi.nlm.nih.gov/6823316/ DOI: 10.1038/301421a0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Sweat duct","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e79498bd-e75d-59d5-9ce4-98c5710e6670","evidence_kind":"source_excerpt","locator":"Lines 874-885","start_line":874,"end_line":885,"excerpt":"### chloride-sweat-reabsorption\nCF sweat ducts showed low chloride permeability and impaired NaCl reabsorption.\nCondition category: machinery_impairment\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A salty sweat measurement can reflect failure to reclaim salt, not excessive intake.\norganism: Human controls and cystic fibrosis patients\ntissue_or_cell_type: Sweat duct\nexperimental_model: Microperfusion of isolated sweat ducts\nlimitations: Predates molecular CFTR identification; does not equate sweat chloride with blood chloride.\nexposure: Cystic fibrosis versus control\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/6823316.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8ce2ab2d15d30590a4e4d13e12060fc8656238cea8856a2aad03ed9e2e4dcee4\", \"start_char\": 0, \"end_char\": 642, \"text_sha256\": \"8ce2ab2d15d30590a4e4d13e12060fc8656238cea8856a2aad03ed9e2e4dcee4\"}\n[chloride-p6823316] Chloride impermeability in cystic fibrosis. 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