{"id":"52659de1-30ee-5740-a43d-a5d575428979","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-histone-enzyme-response","predicate":"reduces","statement":"Fisetin, luteolin and combination treatments reduced histone-acetyltransferase activity in high-glucose-treated human THP-1 cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"620cc4c3-c524-5439-ace7-137c1da1e4e1","mechanism_event_label":"Chromatin-regulating activity accompanied the inflammatory response.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"59f83f8e-63de-5ab0-bfad-5f888da5efa0","slug":"human-thp1-histone-acetyltransferase-activity","display_name":"Histone acetyltransferase activity in human THP-1 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"620cc4c3-c524-5439-ace7-137c1da1e4e1","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-histone-enzyme-response-event","event_type":"observed_relationship","label":"Chromatin-regulating activity accompanied the inflammatory response.","description":"Fisetin, luteolin and combination treatments reduced histone-acetyltransferase activity in high-glucose-treated human THP-1 cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"59f83f8e-63de-5ab0-bfad-5f888da5efa0","slug":"human-thp1-histone-acetyltransferase-activity","display_name":"Histone acetyltransferase activity in human THP-1 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human monocytic cell culture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No unique HAT isoform or direct binding site was resolved in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Chromatin-regulating activity accompanied the inflammatory response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Combination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28650731/ · DOI 10.1089/jmf.2017.3968","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ed0e2c57-05ee-584f-a38f-307fad0b8390","evidence_kind":"source_excerpt","locator":"Lines 448-454","start_line":448,"end_line":454,"excerpt":"## fisetin-histone-enzyme-response\nChromatin-regulating activity accompanied the inflammatory response.\nFisetin, luteolin and combination treatments reduced histone-acetyltransferase activity in high-glucose-treated human THP-1 cells.\nModel: Human monocytic cell culture.\nLimitations: No unique HAT isoform or direct binding site was resolved in the abstract.\nEvidence access: Primary abstract\nCombination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28650731/ · DOI 10.1089/jmf.2017.3968","model_system":"Human monocytic cell culture.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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