{"id":"5243f673-c355-54eb-9dc1-f787d350eca3","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-dopal","predicate":"forms_adducts","statement":"Carnosine reacted with DOPAL and DOPEGAL; glutathione showed little DOPAL reactivity under the tested conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"84b0cdfa-2f87-55fc-ba36-e9286f452fb2","mechanism_event_label":"Different scavengers favor different aldehydes.","subject":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"object":{"id":"440f5100-b8c9-5054-96b7-034b0b0971d6","slug":"carnosine-catecholaldehyde-adducts","display_name":"Carnosine-catecholaldehyde conjugates","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"84b0cdfa-2f87-55fc-ba36-e9286f452fb2","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-dopal-event","event_type":"observed_relationship","label":"Different scavengers favor different aldehydes.","description":"Carnosine reacted with DOPAL and DOPEGAL; glutathione showed little DOPAL reactivity under the tested conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"440f5100-b8c9-5054-96b7-034b0b0971d6","slug":"carnosine-catecholaldehyde-adducts","display_name":"Carnosine-catecholaldehyde conjugates","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6cfad885-c9b9-56bb-8a0e-eac1b20790d2","slug":"dopal","display_name":"3,4-Dihydroxyphenylacetaldehyde / DOPAL","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8e043082-6a19-5f81-be82-d9d0d8dba41d","slug":"dopegal","display_name":"3,4-Dihydroxyphenylglycolaldehyde / DOPEGAL","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Biochemical catecholaldehyde comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No universal antioxidant ranking follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Different scavengers favor different aldehydes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30191330/ · DOI 10.1007/s00726-018-2647-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cc96f707-e191-52b4-bc04-11f31aa183eb","evidence_kind":"source_excerpt","locator":"Lines 276-282","start_line":276,"end_line":282,"excerpt":"## carnosine-dopal\nDifferent scavengers favor different aldehydes.\nCarnosine reacted with DOPAL and DOPEGAL; glutathione showed little DOPAL reactivity under the tested conditions.\nModel: Biochemical catecholaldehyde comparisons.\nLimitations: No universal antioxidant ranking follows.\nEvidence access: Primary abstract\nBiochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30191330/ · DOI 10.1007/s00726-018-2647-y","model_system":"Biochemical catecholaldehyde comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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