{"id":"522644bf-c176-5116-b9cc-6ce185b41e33","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-light-duration","predicate":"shortens","statement":"Prebed room light shortened melatonin duration by about 90 minutes in the analysis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"df21b4c2-9e53-52d9-af72-6c071ac36e2b","mechanism_event_label":"The duration of the signal changed, not just its peak.","subject":{"id":"96c13a2f-84aa-592f-abe5-0c2e3262d83b","slug":"evening-room-light-exposure","display_name":"Evening room-light exposure compared with dim light","entity_type_key":"cellular_process"},"object":{"id":"9635644e-0629-5f92-ab82-e8cef0974647","slug":"melatonin-secretion-duration","display_name":"Duration of endogenous melatonin secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"df21b4c2-9e53-52d9-af72-6c071ac36e2b","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-light-duration-event","event_type":"observed_intervention","label":"The duration of the signal changed, not just its peak.","description":"Prebed room light shortened melatonin duration by about 90 minutes in the analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"96c13a2f-84aa-592f-abe5-0c2e3262d83b","slug":"evening-room-light-exposure","display_name":"Evening room-light exposure compared with dim light","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9635644e-0629-5f92-ab82-e8cef0974647","slug":"melatonin-secretion-duration","display_name":"Duration of endogenous melatonin secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/21193540.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23\", \"start_char\": 0, \"end_char\": 1666, \"text_sha256\": \"899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled-light profiles analyzed retrospectively","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. 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(2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating melatonin under different light conditions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"ef2eeb8a-2680-55c6-aa2e-117edd74604a","evidence_kind":"source_excerpt","locator":"Lines 890-901","start_line":890,"end_line":901,"excerpt":"### melatonin-light-duration\nPrebed room light shortened melatonin duration by about 90 minutes in the analysis.\nCondition category: biomarker_context\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The duration of the signal changed, not just its peak.\norganism: 116 healthy adults aged 18-30\ntissue_or_cell_type: Circulating melatonin under different light conditions\nexperimental_model: Controlled-light profiles analyzed retrospectively\nlimitations: Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency.\nexposure: Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/21193540.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23\", \"start_char\": 0, \"end_char\": 1666, \"text_sha256\": \"899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23\"}\n[melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098","model_system":"Controlled-light profiles analyzed retrospectively","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}