{"id":"51e22d12-d1d2-5d46-ad82-1c2a43a42f6c","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-alcohol-ileal-zinc","predicate":"reduces","statement":"Alcohol exposure significantly reduced the ileal zinc concentration in association with accumulation of reactive oxygen species, and significantly increased permeability of the ileum without affecting the duodenum or jejunum.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1ad44043-0a4e-58f7-bd57-5590a5309e00","mechanism_event_label":"Alcohol drains zinc from one specific stretch of gut, and that is exactly where it leaks.","subject":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"object":{"id":"4c433b93-3a72-5538-bc4f-41967006374c","slug":"ileal-zinc-concentration","display_name":"Ileal tissue zinc concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1ad44043-0a4e-58f7-bd57-5590a5309e00","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-alcohol-ileal-zinc-event","event_type":"biochemical_relationship","label":"Alcohol drains zinc from one specific stretch of gut, and that is exactly where it leaks.","description":"Alcohol exposure significantly reduced the ileal zinc concentration in association with accumulation of reactive oxygen species, and significantly increased permeability of the ileum without affecting the duodenum or jejunum.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"depleted_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e653568c-ba57-5379-80a9-18ae320391b6","slug":"intestinal-permeability","display_name":"Intestinal permeability to macromolecules","entity_type_key":"cellular_process"},"role":"downstream_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4c433b93-3a72-5538-bc4f-41967006374c","slug":"ileal-zinc-concentration","display_name":"Ileal tissue zinc concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/20167873.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e\", \"start_char\": 0, \"end_char\": 1542, \"text_sha256\": \"12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pair-fed alcohol mice with regional permeability measurement and Caco-2 zinc deprivation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Four weeks of alcohol liquid diet; zinc deprivation in culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The regional specificity and the separate zinc-deprivation arm are what make the nutrient claim interpretable. The exaggeration experiment is in cultured cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Alcohol drains zinc from one specific stretch of gut, and that is exactly where it leaks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p20167873] The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. (2010). https://pubmed.ncbi.nlm.nih.gov/20167873/ DOI: 10.1152/ajpgi.00350.2009","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ileum and Caco-2 monolayers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3156f1f9-b80a-5ba3-b918-1298d2f66912","evidence_kind":"source_excerpt","locator":"Lines 761-772","start_line":761,"end_line":772,"excerpt":"### alcohol-alcohol-ileal-zinc\nAlcohol exposure significantly reduced the ileal zinc concentration in association with accumulation of reactive oxygen species, and significantly increased permeability of the ileum without affecting the duodenum or jejunum.\nCondition category: nutrient_deficiency\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: Alcohol drains zinc from one specific stretch of gut, and that is exactly where it leaks.\norganism: Mouse\ntissue_or_cell_type: Ileum and Caco-2 monolayers\nexperimental_model: Pair-fed alcohol mice with regional permeability measurement and Caco-2 zinc deprivation\nlimitations: The regional specificity and the separate zinc-deprivation arm are what make the nutrient claim interpretable. The exaggeration experiment is in cultured cells.\nexposure: Four weeks of alcohol liquid diet; zinc deprivation in culture\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/20167873.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e\", \"start_char\": 0, \"end_char\": 1542, \"text_sha256\": \"12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e\"}\n[alcohol-p20167873] The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. (2010). https://pubmed.ncbi.nlm.nih.gov/20167873/ DOI: 10.1152/ajpgi.00350.2009","model_system":"Pair-fed alcohol mice with regional permeability measurement and Caco-2 zinc deprivation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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