{"id":"51e21d8a-5b1e-5495-ac49-dae09f5565da","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-transport-pdxp-pnp","predicate":"dephosphorylates","statement":"Catalytically active recombinant human pyridoxal phosphatase hydrolyzed pyridoxine-phosphate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1a95294c-0bdd-5cc3-ae1a-6d40c6118401","mechanism_event_label":"PDXP removes phosphate from a B6 vitamer.","subject":{"id":"a0d74853-72b7-546d-a7c7-d37602ba990a","slug":"pdxp","display_name":"Human pyridoxal phosphatase / PDXP","entity_type_key":"protein"},"object":{"id":"be0df099-29bf-56ce-b60b-6c6cfb912bb1","slug":"pyridoxine-phosphate","display_name":"Pyridoxine 5-prime-phosphate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"1a95294c-0bdd-5cc3-ae1a-6d40c6118401","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-transport-pdxp-pnp-event","event_type":"biochemical_relationship","label":"PDXP removes phosphate from a B6 vitamer.","description":"Catalytically active recombinant human pyridoxal phosphatase hydrolyzed pyridoxine-phosphate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"be0df099-29bf-56ce-b60b-6c6cfb912bb1","slug":"pyridoxine-phosphate","display_name":"Pyridoxine 5-prime-phosphate","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"role":"dephosphorylated product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b28dfc54-a5ef-5f9e-ac1f-890b68e58dc3","slug":"inorganic-phosphate","display_name":"Inorganic phosphate","entity_type_key":"chemical_species"},"role":"released phosphate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a0d74853-72b7-546d-a7c7-d37602ba990a","slug":"pdxp","display_name":"Human pyridoxal phosphatase / PDXP","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_location","value_text":"Indexed abstract: cloning and substrate hydrolysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human pyridoxal phosphatase expressed in E. coli.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Recombinant-enzyme characterization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Model-specific evidence; no dietary threshold or treatment benefit established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"PDXP removes phosphate from a B6 vitamer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[jang2003] Human pyridoxal phosphatase. 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