{"id":"516e5a5b-6959-56c8-bc8b-0f6284573853","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-alone-does-not-improve-blood-lipids","predicate":"does_not_change","statement":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"647943b2-d424-57b2-8b06-7b732f143589","mechanism_event_label":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","subject":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"59b27f87-63a9-500e-9912-6c8863d9766b","slug":"blood-ldl-cholesterol","display_name":"Blood low-density lipoprotein cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"647943b2-d424-57b2-8b06-7b732f143589","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-alone-does-not-improve-blood-lipids-event","event_type":"observed_intervention","label":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","description":"Blood lipids","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"59b27f87-63a9-500e-9912-6c8863d9766b","slug":"blood-ldl-cholesterol","display_name":"Blood low-density lipoprotein cholesterol concentration","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"6 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (47 patients with hyperlipidemia in three arms)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase 50 mg per capsule, two capsules twice daily, alone or with 300 mg red yeast rice extract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Randomized, double-blind and placebo-controlled but small. The combination arm cannot attribute anything to the nattokinase, since red yeast rice contains monacolin K. The mono-arm null is the informative part.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (47 patients with hyperlipidemia in three arms)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia. (2009) https://pubmed.ncbi.nlm.nih.gov/19786378/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo, oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Blood lipids","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e34f74d3-e81a-54db-a71e-673b239087a7","evidence_kind":"source_excerpt","locator":"Lines 1214-1214","start_line":1214,"end_line":1214,"excerpt":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","model_system":"Human (47 patients with hyperlipidemia in three arms)","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[{"id":"5f4863da-1fba-5270-87d2-ee752a7e1b97","relation_type":"contradicts","notes":"A randomized placebo-controlled mono-arm found no lipid effect over six months where the uncontrolled cohort reports significant improvement.","source_claim_id":"516e5a5b-6959-56c8-bc8b-0f6284573853","source_claim_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-alone-does-not-improve-blood-lipids","source_statement":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","target_claim_id":"7c5092e7-475a-58ca-9738-90ac955f6222","target_claim_key":"33bef151-bdc7-5892-aff6-0345ab149739:a-retrospective-cohort-reports-plaque-reduction-at-high-dose","target_statement":"In a retrospective cohort of 1,062 participants, 10,800 FU per day for 12 months was followed by reduced carotid intima-media thickness and carotid plaque size, with improvement rates of 66.5 to 95.4%."}],"conflicts":[{"id":"209a9142-3c57-534c-ac48-a7cfe8887122","title":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-alone-does-not-improve-blood-lipids / 33bef151-bdc7-5892-aff6-0345ab149739:a-retrospective-cohort-reports-plaque-reduction-at-high-dose","kind":"contradicts","status":"recorded_relation","why":"The ledger explicitly records that ‘A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.’ contradicts ‘In a retrospective cohort of 1,062 participants, 10,800 FU per day for 12 months was followed by reduced carotid intima-media thickness and carotid plaque size, with improvement rates of 66.5 to 95.4%.’. A randomized placebo-controlled mono-arm found no lipid effect over six months where the uncontrolled cohort reports significant improvement.","resolution":"Both statements and their source versions are retained. Review their experimental contexts and supporting evidence before resolving the disagreement.","created_at":"2026-10-02 02:42:45","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/209a9142-3c57-534c-ac48-a7cfe8887122","sides":[{"conflict_id":"209a9142-3c57-534c-ac48-a7cfe8887122","ordinal":0,"label":"Related statement","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","start_line":1214,"end_line":1214,"quote":"A nattokinase-only formula showed no effect on blood lipids through six months, while the same enzyme combined with red yeast rice improved every lipid measured from month one.","source_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","source_title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","claim_ids":["516e5a5b-6959-56c8-bc8b-0f6284573853"]},{"conflict_id":"209a9142-3c57-534c-ac48-a7cfe8887122","ordinal":1,"label":"Opposing statement","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","start_line":1148,"end_line":1148,"quote":"In a retrospective cohort of 1,062 participants, 10,800 FU per day for 12 months was followed by reduced carotid intima-media thickness and carotid plaque size, with improvement rates of 66.5 to 95.4%.","source_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","source_title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","claim_ids":["7c5092e7-475a-58ca-9738-90ac955f6222"]}]}],"corrections":[],"research":null}