{"id":"514caf2f-a507-50c0-81c0-0b5a4d95ed6e","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-probenecid-exposure","predicate":"increases_in_recorded_comparison","statement":"Probenecid co-injection increased rat RA AUC while reducing renal excretion.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1bd111b3-5fbf-502f-9088-74a87c3a7fc7","mechanism_event_label":"Probenecid co-injection increased rat RA AUC while reducing renal excretion.","subject":{"id":"ae90b5b9-8e81-5788-b32c-56abc20c0ca6","slug":"probenecid","display_name":"Probenecid","entity_type_key":"small_molecule"},"object":{"id":"ccc3d0a7-493f-5bce-a618-e58ea4ef1b3f","slug":"rat-ra-exposure","display_name":"Rat plasma RA exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1bd111b3-5fbf-502f-9088-74a87c3a7fc7","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-probenecid-exposure-event","event_type":"experimental_observation","label":"Probenecid co-injection increased rat RA AUC while reducing renal excretion.","description":"### ra-probenecid-exposure\n\nProbenecid co-injection increased rat RA AUC while reducing renal excretion.\nMechanistic support for anion-transporter-dependent elimination; not human oral exposure.\nModel and exposure: Rat IV study; Table 2 and Figure 4.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33435470/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7828042/ | https://doi.org/10.3390/pharmaceutics13010083 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ae90b5b9-8e81-5788-b32c-56abc20c0ca6","slug":"probenecid","display_name":"Probenecid","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"IV RA plus probenecid","sequence_order":0,"notes":""},{"entity":{"id":"ccc3d0a7-493f-5bce-a618-e58ea4ef1b3f","slug":"rat-ra-exposure","display_name":"Rat plasma RA exposure","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"measured substrate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"IV RA plus probenecid\", \"comparator\": \"IV RA alone\", \"endpoint\": \"Probenecid co-injection increased rat RA AUC while reducing renal excretion.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Rat IV study; Table 2 and Figure 4.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Probenecid co-injection increased rat RA AUC while reducing renal excretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid. | https://pubmed.ncbi.nlm.nih.gov/33435470/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7828042/ | https://doi.org/10.3390/pharmaceutics13010083","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-probenecid-exposure; Mechanistic support for anion-transporter-dependent elimination; not human oral exposure.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"87ced9c6-bcac-5039-8a30-c00324e88586","evidence_kind":"source_excerpt","locator":"Lines 405-411","start_line":405,"end_line":411,"excerpt":"### ra-probenecid-exposure\n\nProbenecid co-injection increased rat RA AUC while reducing renal excretion.\nMechanistic support for anion-transporter-dependent elimination; not human oral exposure.\nModel and exposure: Rat IV study; Table 2 and Figure 4.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33435470/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7828042/ | https://doi.org/10.3390/pharmaceutics13010083 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"Rat IV study; Table 2 and Figure 4.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}