{"id":"513bc214-8054-5ed6-ae04-df797c4d6801","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-pad-walking","predicate":"attenuates_trial_improvement","statement":"Walking distance improved less with arginine than placebo in the six-month PAD trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"af2522ed-8c76-5192-8628-90c87148740c","mechanism_event_label":"The functional outcome did not follow the expected supplement benefit.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"f53ed5be-0df6-5d69-afe9-7e8d0a886d15","slug":"pad-walking-capacity","display_name":"Treadmill claudication distance in peripheral arterial disease","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"af2522ed-8c76-5192-8628-90c87148740c","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-pad-walking-event","event_type":"observed_relationship","label":"The functional outcome did not follow the expected supplement benefit.","description":"Walking distance improved less with arginine than placebo in the six-month PAD trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f53ed5be-0df6-5d69-afe9-7e8d0a886d15","slug":"pad-walking-capacity","display_name":"Treadmill claudication distance in peripheral arterial disease","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"NO-PAIN randomized trial; treadmill claudication distance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not isolate why shorter and longer studies differ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The functional outcome did not follow the expected supplement benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17592080/ · DOI 10.1161/circulationaha.106.683656","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"25f9efab-05f7-5f4f-b1b1-3f8d31401893","evidence_kind":"source_excerpt","locator":"Lines 398-404","start_line":398,"end_line":404,"excerpt":"## arg-pad-walking\nThe functional outcome did not follow the expected supplement benefit.\nWalking distance improved less with arginine than placebo in the six-month PAD trial.\nModel: NO-PAIN randomized trial; treadmill claudication distance.\nLimitations: Does not isolate why shorter and longer studies differ.\nEvidence access: Primary abstract\nL-arginine supplementation in peripheral arterial disease: no benefit and possible harm. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17592080/ · DOI 10.1161/circulationaha.106.683656","model_system":"NO-PAIN randomized trial; treadmill claudication distance.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}