{"id":"512054c3-a917-5ddc-98e3-8b68d8906412","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-cx3cr1-loss","predicate":"when_deleted_prevents_tested","statement":"Monocyte/macrophage Cx3cr1 deletion abolished aspartame-exacerbated atherosclerosis in the model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"27f4d978-8e97-5242-8197-e1786006312e","mechanism_event_label":"A separate immune receptor was required for the added plaque effect.","subject":{"id":"0e249233-91cb-571d-b489-60917fc4bcff","slug":"mouse-cx3cr1","display_name":"Mouse fractalkine receptor / Cx3cr1","entity_type_key":"protein"},"object":{"id":"256296a9-0ea5-54bd-b890-202c0e427f64","slug":"apo-e-null-mouse-aspartame-atherosclerosis","display_name":"ApoE-null mouse atherosclerosis during aspartame exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"27f4d978-8e97-5242-8197-e1786006312e","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-cx3cr1-loss-event","event_type":"observed_relationship","label":"A separate immune receptor was required for the added plaque effect.","description":"Monocyte/macrophage Cx3cr1 deletion abolished aspartame-exacerbated atherosclerosis in the model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e249233-91cb-571d-b489-60917fc4bcff","slug":"mouse-cx3cr1","display_name":"Mouse fractalkine receptor / Cx3cr1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"256296a9-0ea5-54bd-b890-202c0e427f64","slug":"apo-e-null-mouse-aspartame-atherosclerosis","display_name":"ApoE-null mouse atherosclerosis during aspartame exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"57072c13-fc08-579d-90af-1e28eb87eac5","slug":"2025-arterial-cell-cx3cl1","display_name":"Arterial-cell CX3CL1 in the 2025 aspartame study, species unresolved","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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