{"id":"51080944-e9b0-5b29-b8b0-841a4c69e63c","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-oral-im-clinical-response","predicate":"both_studied_routes_improved_clinical_findings","statement":"The oral and IM groups showed prompt, indistinguishable improvement in hematologic and neurologic abnormalities.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"6ff6b72f-d458-5ff2-a90b-e1762fe71e00","mechanism_event_label":"Absorption through the usual food route was not required for every effective replacement regimen in this trial.","subject":{"id":"4cb4dfbc-6cd9-5bd5-98dc-d0a8fb6cfee4","slug":"cyanocobalamin","display_name":"Cyanocobalamin","entity_type_key":"small_molecule"},"object":{"id":"e058a824-b021-58a0-bcde-d9fb7883b142","slug":"b12-neurologic-recovery","display_name":"Neurologic recovery following B12 replacement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6ff6b72f-d458-5ff2-a90b-e1762fe71e00","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-oral-im-clinical-response-event","event_type":"observed_intervention","label":"Absorption through the usual food route was not required for every effective replacement regimen in this trial.","description":"The oral and IM groups showed prompt, indistinguishable improvement in hematologic and neurologic abnormalities.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4cb4dfbc-6cd9-5bd5-98dc-d0a8fb6cfee4","slug":"cyanocobalamin","display_name":"Cyanocobalamin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e058a824-b021-58a0-bcde-d9fb7883b142","slug":"b12-neurologic-recovery","display_name":"Neurologic recovery following B12 replacement","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Randomized oral-versus-intramuscular study: 38 allocated; five subsequently identified as folate deficient excluded, leaving 18 oral and 15 injection participants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cyanocobalamin 2 mg orally each day for 120 days versus 1 mg IM on days 1, 3, 7, 10, 14, 21, 30, 60 and 90. Unequal cumulative exposures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small evaluable groups do not establish equivalence for every severe presentation or rare processing disorder.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Absorption through the usual food route was not required for every effective replacement regimen in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b12-kuzminski1998] Effective treatment of cobalamin deficiency with oral cobalamin (1998). https://pubmed.ncbi.nlm.nih.gov/9694707/ DOI: 10.1182/blood.v92.4.1191","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5fa6db64-aea6-5ac0-a3f2-2a17bc1dac77","evidence_kind":"source_excerpt","locator":"Lines 1685-1695","start_line":1685,"end_line":1695,"excerpt":"### b12-oral-im-clinical-response\nThe oral and IM groups showed prompt, indistinguishable improvement in hematologic and neurologic abnormalities.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Absorption through the usual food route was not required for every effective replacement regimen in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Randomized oral-versus-intramuscular study: 38 allocated; five subsequently identified as folate deficient excluded, leaving 18 oral and 15 injection participants.\nlimitations: Small evaluable groups do not establish equivalence for every severe presentation or rare processing disorder.\nexposure: Cyanocobalamin 2 mg orally each day for 120 days versus 1 mg IM on days 1, 3, 7, 10, 14, 21, 30, 60 and 90. Unequal cumulative exposures.\n[b12-kuzminski1998] Effective treatment of cobalamin deficiency with oral cobalamin (1998). https://pubmed.ncbi.nlm.nih.gov/9694707/ DOI: 10.1182/blood.v92.4.1191","model_system":"Randomized oral-versus-intramuscular study: 38 allocated; five subsequently identified as folate deficient excluded, leaving 18 oral and 15 injection participants.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-kuzminski1998] Effective treatment of cobalamin deficiency with oral cobalamin (1998). https://pubmed.ncbi.nlm.nih.gov/9694707/ DOI: 10.1182/blood.v92.4.1191","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}