{"id":"50d38919-8cd5-582b-b7bd-09bab39b915d","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-extract-pgp","predicate":"inhibits_tested","statement":"The three product extracts inhibited P-glycoprotein transport activity more potently than pure lovastatin in the study assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a7380368-b734-5f32-8d51-0747ee2f8dae","mechanism_event_label":"An efflux transporter provides another exposure-related route.","subject":{"id":"479f127b-18e1-54db-b4d0-720ceaa77e28","slug":"ryr-methanol-extract-panel-2012","display_name":"LipoCol Forte, Xuezhikang and Cholestin extract panel studied in 2012","entity_type_key":"chemical_species"},"object":{"id":"c6139b52-4140-5622-9e33-1f6c6385265d","slug":"abcb1","display_name":"Human P-glycoprotein / ABCB1 / MDR1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"a7380368-b734-5f32-8d51-0747ee2f8dae","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-extract-pgp-event","event_type":"observed_relationship","label":"An efflux transporter provides another exposure-related route.","description":"The three product extracts inhibited P-glycoprotein transport activity more potently than pure lovastatin in the study assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"479f127b-18e1-54db-b4d0-720ceaa77e28","slug":"ryr-methanol-extract-panel-2012","display_name":"LipoCol Forte, Xuezhikang and Cholestin extract panel studied in 2012","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c6139b52-4140-5622-9e33-1f6c6385265d","slug":"abcb1","display_name":"Human P-glycoprotein / ABCB1 / MDR1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text PMC3513969","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Canine MDCK cells engineered with human MDR1; radiolabeled digoxin probe.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human transporter in a canine host cell; not a clinical digoxin-interaction magnitude.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"An efflux transporter provides another exposure-related route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0fe2cd68-04c9-5311-a1de-1905b1dcd65e","evidence_kind":"source_excerpt","locator":"Lines 132-138","start_line":132,"end_line":138,"excerpt":"## red-yeast-rice-extract-pgp\nAn efflux transporter provides another exposure-related route.\nThe three product extracts inhibited P-glycoprotein transport activity more potently than pure lovastatin in the study assay.\nModel: Canine MDCK cells engineered with human MDR1; radiolabeled digoxin probe.\nLimitations: Human transporter in a canine host cell; not a clinical digoxin-interaction magnitude.\nEvidence access: Primary full text PMC3513969\n[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","model_system":"Canine MDCK cells engineered with human MDR1; radiolabeled digoxin probe.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}