{"id":"50bc4cd6-0650-585f-8a8a-0c3acd045406","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-iron-salt-volume","predicate":"repletion-improves","statement":"At 20 weeks, thyroid volume fell 22.8 ± 10.7% with iron treatment versus 12.7 ± 10.1% with placebo in children already using iodized salt (P<0.01).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"efc51d7b-c57b-5464-b0be-3b4bc895c2af","mechanism_event_label":"Correcting iron deficiency improved the thyroid-size response while iodine was supplied.","subject":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"object":{"id":"ae8b47e9-be28-594e-af38-0a535249e9db","slug":"thyroid-volume","display_name":"Thyroid volume","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"efc51d7b-c57b-5464-b0be-3b4bc895c2af","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-iron-salt-volume-event","event_type":"observed_intervention","label":"Correcting iron deficiency improved the thyroid-size response while iodine was supplied.","description":"At 20 weeks, thyroid volume fell 22.8 ± 10.7% with iron treatment versus 12.7 ± 10.1% with placebo in children already using iodized salt (P<0.01).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"iodine supplied in both groups","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2d1c1d41-eea1-5a33-9312-e1e94bcb2a15","slug":"iodized-salt","display_name":"Iodized salt preparation","entity_type_key":"chemical_species"},"role":"shared background intervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ae8b47e9-be28-594e-af38-0a535249e9db","slug":"thyroid-volume","display_name":"Thyroid volume","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"All consumed iodized salt providing 10–30 mg iodine/kg salt at household level; iron group received 60 mg elemental Fe/day, four days/week for 16 weeks; outcomes followed to 20 weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This tests iron treatment on a background of iodine supply. It does not directly measure TPO activity or prove that iron deficiency always prevents iodine response. Specific iron-supplement salt not verified from abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Correcting iron deficiency improved the thyroid-size response while iodine was supplied.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. (2002). https://pubmed.ncbi.nlm.nih.gov/11916762/ DOI: 10.1093/ajcn/75.4.743","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thyroid ultrasound and blood thyroid indices","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"86b4ca03-fd66-5868-b29b-f0cfe00a67a3","evidence_kind":"source_excerpt","locator":"Lines 1202-1214","start_line":1202,"end_line":1214,"excerpt":"### iod-clin-iron-salt-volume\nAt 20 weeks, thyroid volume fell 22.8 ± 10.7% with iron treatment versus 12.7 ± 10.1% with placebo in children already using iodized salt (P<0.01).\nCondition category: nutrient_deficiency\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Correcting iron deficiency improved the thyroid-size response while iodine was supplied.\norganism: Homo sapiens\ntissue_or_cell_type: Thyroid ultrasound and blood thyroid indices\nexperimental_model: Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire\nlimitations: This tests iron treatment on a background of iodine supply. It does not directly measure TPO activity or prove that iron deficiency always prevents iodine response. Specific iron-supplement salt not verified from abstract.\nexposure: All consumed iodized salt providing 10–30 mg iodine/kg salt at household level; iron group received 60 mg elemental Fe/day, four days/week for 16 weeks; outcomes followed to 20 weeks.\ncross_nutrient: true\nevidence_location: Primary indexed abstract.\n[iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. (2002). https://pubmed.ncbi.nlm.nih.gov/11916762/ DOI: 10.1093/ajcn/75.4.743","model_system":"Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. (2002). https://pubmed.ncbi.nlm.nih.gov/11916762/ DOI: 10.1093/ajcn/75.4.743","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}