{"id":"50a9b7b1-db08-5522-ac27-895a087a223c","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-maternal-global-null","predicate":"has_no_significant_effect","statement":"The PC supplementation and placebo groups did not differ significantly in global development at the reported infant follow-up assessments.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a8515a69-a1c6-5bed-a799-6276470b1913","mechanism_event_label":"This measured outcome did not improve significantly in the trial.","subject":{"id":"35adb31d-18cf-5997-9e73-8e5c54d84336","slug":"phosphatidylcholine-supplement","display_name":"Study-specific phosphatidylcholine supplements","entity_type_key":"chemical_species"},"object":{"id":"4c81901f-dd31-5cff-ba0e-60cb0860f7be","slug":"infant-global-development-2012","display_name":"Infant global-development score in the 2012 PC supplementation trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a8515a69-a1c6-5bed-a799-6276470b1913","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-maternal-global-null-event","event_type":"observed_intervention","label":"This measured outcome did not improve significantly in the trial.","description":"The PC supplementation and placebo groups did not differ significantly in global development at the reported infant follow-up assessments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"35adb31d-18cf-5997-9e73-8e5c54d84336","slug":"phosphatidylcholine-supplement","display_name":"Study-specific phosphatidylcholine supplements","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4c81901f-dd31-5cff-ba0e-60cb0860f7be","slug":"infant-global-development-2012","display_name":"Infant global-development score in the 2012 PC supplementation trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/23134891.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e\", \"start_char\": 0, \"end_char\": 1592, \"text_sha256\": \"c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled maternal PC supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"750 mg choline/day delivered as PC, not 750 mg PC mass; weeks 18 through 90 days postpartum; background food choline about 360 mg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dose identity checked in full-text intervention section. Different endpoints, timing and feeding control from the 2018 trial; a null result is not proof of no effect on every possible outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Choline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This measured outcome did not improve significantly in the trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[choline-p23134891] Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23134891/ DOI: 10.3945/ajcn.112.037184","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"140 randomized women; 99 infants in follow-up","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"38ecfdf0-86dd-567b-9925-432a7fd94df2","evidence_kind":"source_excerpt","locator":"Lines 1270-1281","start_line":1270,"end_line":1281,"excerpt":"### choline-maternal-global-null\nThe PC supplementation and placebo groups did not differ significantly in global development at the reported infant follow-up assessments.\nCondition category: normal\nnutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This measured outcome did not improve significantly in the trial.\norganism: Human\ntissue_or_cell_type: 140 randomized women; 99 infants in follow-up\nexperimental_model: Randomized double-blind placebo-controlled maternal PC supplementation\nlimitations: Dose identity checked in full-text intervention section. Different endpoints, timing and feeding control from the 2018 trial; a null result is not proof of no effect on every possible outcome.\nexposure: 750 mg choline/day delivered as PC, not 750 mg PC mass; weeks 18 through 90 days postpartum; background food choline about 360 mg/day\nevidence_span: {\"source_cache\": \"artifacts/choline-research/23134891.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e\", \"start_char\": 0, \"end_char\": 1592, \"text_sha256\": \"c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e\"}\n[choline-p23134891] Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23134891/ DOI: 10.3945/ajcn.112.037184","model_system":"Randomized double-blind placebo-controlled maternal PC supplementation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [choline-p23134891] Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. 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