{"id":"5091b945-3610-501d-8447-126c9e4324b9","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-tollip","predicate":"increases","statement":"EGCG rapidly increased Tollip expression; 67LR silencing or antibody blockade prevented this.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0b066524-3e33-5b8e-bcfb-d827e3ae72b8","mechanism_event_label":"EGCG increased a brake on inflammatory signaling.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"56458b90-9afc-54bd-9801-7ea87c866b53","slug":"tollip-expression","display_name":"Tollip expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0b066524-3e33-5b8e-bcfb-d827e3ae72b8","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-tollip-event","event_type":"observed_relationship","label":"EGCG increased a brake on inflammatory signaling.","description":"EGCG rapidly increased Tollip expression; 67LR silencing or antibody blockade prevented this.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"56458b90-9afc-54bd-9801-7ea87c866b53","slug":"tollip-expression","display_name":"Tollip expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0c3e9bd5-2972-5f55-a80c-fd5d7d40ca5c","slug":"tollip-family","display_name":"Toll-interacting protein family / Tollip","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Family nodes preserve the unresolved species. This is not evidence of treating systemic human inflammation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"EGCG increased a brake on inflammatory signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20511545/ · DOI 10.4049/jimmunol.0903742","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"62b55b6f-3713-5624-9b2f-ee7d4c736a90","evidence_kind":"source_excerpt","locator":"Lines 100-106","start_line":100,"end_line":106,"excerpt":"## egcg-tollip\nEGCG increased a brake on inflammatory signaling.\nEGCG rapidly increased Tollip expression; 67LR silencing or antibody blockade prevented this.\nModel: Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.\nLimitations: Family nodes preserve the unresolved species. This is not evidence of treating systemic human inflammation.\nEvidence access: primary abstract.\nTLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20511545/ · DOI 10.4049/jimmunol.0903742","model_system":"Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}