{"id":"50810a78-6404-5180-8b7e-0c61666f45b8","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-hfd-microbiota","predicate":"alters","statement":"Oral indicaxanthin altered gut microbial relative abundances in high-fat-diet-fed male mice.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e0ef1111-eed2-554c-96b1-431907ce8144","mechanism_event_label":"Oral indicaxanthin altered gut microbial relative abundances in high-fat-diet-fed male mice.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"d093cbe9-88cf-5948-aa6f-3e661ee0a1c1","slug":"mouse-hfd-gut-microbiota-composition","display_name":"Gut microbial composition in high-fat-diet-fed mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e0ef1111-eed2-554c-96b1-431907ce8144","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-hfd-microbiota-event","event_type":"observed_relationship","label":"Oral indicaxanthin altered gut microbial relative abundances in high-fat-diet-fed male mice.","description":"Oral indicaxanthin altered gut microbial relative abundances in high-fat-diet-fed male mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d093cbe9-88cf-5948-aa6f-3e661ee0a1c1","slug":"mouse-hfd-gut-microbiota-composition","display_name":"Gut microbial composition in high-fat-diet-fed mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"High-fat diet for 10 weeks then indicaxanthin for 4 weeks; abstract reports 0.86 mg/kg/day, methods state 0.4 mg/kg twice daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"4 treatment weeks; eight mice/group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary open full text, relevant results/methods and PubMed metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male mice with diet-induced obesity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dose wording differs between abstract and methods and is preserved unresolved. Changes in microbial abundance do not demonstrate measured SCFA production or microbiota-mediated causation of brain changes. Article assigned 2026 issue; earlier online indexing retained in PubMed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Male mice with diet-induced obesity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Oral indicaxanthin altered gut microbial relative abundances in high-fat-diet-fed male mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet-induced neuronal damage and gut microbiota dysbiosis. (2026). https://pubmed.ncbi.nlm.nih.gov/39314163/ DOI: 10.4103/NRR.NRR-D-23-02039","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral indicaxanthin in water","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cerebral cortex and gut microbiota","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c6b2a6dc-1481-5b78-af4e-b30e2fdb4620","evidence_kind":"source_excerpt","locator":"Lines 481-490","start_line":481,"end_line":490,"excerpt":"## indicaxanthin-hfd-microbiota\nOral indicaxanthin altered gut microbial relative abundances in high-fat-diet-fed male mice.\nModel/species: Male mice with diet-induced obesity\nTissue: Cerebral cortex and gut microbiota\nExposure: High-fat diet for 10 weeks then indicaxanthin for 4 weeks; abstract reports 0.86 mg/kg/day, methods state 0.4 mg/kg twice daily\nRoute: Oral indicaxanthin in water\nDuration: 4 treatment weeks; eight mice/group\nLimits: Dose wording differs between abstract and methods and is preserved unresolved. Changes in microbial abundance do not demonstrate measured SCFA production or microbiota-mediated causation of brain changes. Article assigned 2026 issue; earlier online indexing retained in PubMed.\nPrimary reference: Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet-induced neuronal damage and gut microbiota dysbiosis. (2026). https://pubmed.ncbi.nlm.nih.gov/39314163/ DOI: 10.4103/NRR.NRR-D-23-02039\nAccess: Primary open full text, relevant results/methods and PubMed metadata.","model_system":"Male mice with diet-induced obesity","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. 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