{"id":"5047163f-f0b1-5f51-8703-7efd6f91b4b7","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-human-hcy-null","predicate":"did_not_significantly_reduce","statement":"Creatine alone did not significantly lower total plasma homocysteine compared with placebo (P=0.35).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1f216682-711f-5b79-abd1-2e09da4b5ac5","mechanism_event_label":"Reducing precursor production did not automatically produce a lower homocysteine result in people.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"1f216682-711f-5b79-abd1-2e09da4b5ac5","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-human-hcy-null-event","event_type":"observed_intervention","label":"Reducing precursor production did not automatically produce a lower homocysteine result in people.","description":"Creatine alone did not significantly lower total plasma homocysteine compared with placebo (P=0.35).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/26311810.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"055a97365d5a6d864e78eafcfa4a73bc8c425e240487580796a443cf8ef33a04\", \"start_char\": 0, \"end_char\": 2160, \"text_sha256\": \"055a97365d5a6d864e78eafcfa4a73bc8c425e240487580796a443cf8ef33a04\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve-week randomized placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Creatine 3 g/day, folic acid 400 micrograms/day, both, or placebo; analyzed groups 101, 153, 103 and 101 respectively","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Group-average effects and exploratory within-person associations are distinct. No general claim of restored methylation or reduced disease risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Bangladeshi adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Reducing precursor production did not automatically produce a lower homocysteine result in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p26311810] Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26311810/ DOI: 10.3945/jn.115.216739","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma metabolites","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"780427d2-b74b-5178-9f3d-90f39d018a55","evidence_kind":"source_excerpt","locator":"Lines 737-748","start_line":737,"end_line":748,"excerpt":"### creatine-human-hcy-null\nCreatine alone did not significantly lower total plasma homocysteine compared with placebo (P=0.35).\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Reducing precursor production did not automatically produce a lower homocysteine result in people.\norganism: Bangladeshi adults\ntissue_or_cell_type: Plasma metabolites\nexperimental_model: Twelve-week randomized placebo-controlled trial\nlimitations: Group-average effects and exploratory within-person associations are distinct. No general claim of restored methylation or reduced disease risk.\nexposure: Creatine 3 g/day, folic acid 400 micrograms/day, both, or placebo; analyzed groups 101, 153, 103 and 101 respectively\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/26311810.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"055a97365d5a6d864e78eafcfa4a73bc8c425e240487580796a443cf8ef33a04\", \"start_char\": 0, \"end_char\": 2160, \"text_sha256\": \"055a97365d5a6d864e78eafcfa4a73bc8c425e240487580796a443cf8ef33a04\"}\n[creatine-p26311810] Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial. 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