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Affinities are assay values, not human tissue concentrations, and renal handling was governed by other transporters in this model.\nexposure: Intravenous metformin in Oct1(-/-) and Oct1(+/+) mice; buformin and phenformin compared in vitro\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/12130709.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2bd4b1f58d2b0b30807a1a521298f4713a86049a53f62cfc5d6463927644d82b\", \"start_char\": 0, \"end_char\": 1411, \"text_sha256\": \"2bd4b1f58d2b0b30807a1a521298f4713a86049a53f62cfc5d6463927644d82b\"}\n[metformin-p12130709] Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. 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