{"id":"501adbd8-fcd8-534c-bb12-f67d2cd75816","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-microbial-deglycosylation","predicate":"microbially_converted_to","statement":"Human-donor intestinal bacterial cultures yielded Myricetin through the reported deglycosylation route.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3b866d02-d98d-527e-9d75-a1c0f4da9a11","mechanism_event_label":"Gut processing produces a chemically different molecule.","subject":{"id":"284758a3-4771-53c3-956f-b374ada7d59b","slug":"myricitrin","display_name":"Myricitrin / myricetin 3-O-rhamnoside","entity_type_key":"small_molecule"},"object":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"3b866d02-d98d-527e-9d75-a1c0f4da9a11","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-microbial-deglycosylation-event","event_type":"observed_relationship","label":"Gut processing produces a chemically different molecule.","description":"Human-donor intestinal bacterial cultures yielded Myricetin through the reported deglycosylation route.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"284758a3-4771-53c3-956f-b374ada7d59b","slug":"myricitrin","display_name":"Myricitrin / myricetin 3-O-rhamnoside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"97691737-2666-534d-b86a-e35a65d02f6f","slug":"human-donor-myricitrin-metabolizing-isolates","display_name":"Myricitrin-metabolizing intestinal isolates from one human donor","entity_type_key":"organism"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four active isolates selected from about 100 colonies from one healthy female donor; most identified as Escherichia.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mass-spectrometric pathway assignment; no specific enzyme or population-wide conversion rate established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Gut processing produces a chemically different molecule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Identification of the metabolites of myricitrin produced by human intestinal bacteria in vitro using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24882500/ · DOI 10.1517/17425255.2014.918954","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34aaaf5a-e11e-5715-bff2-0feef1fe8a8e","evidence_kind":"source_excerpt","locator":"Lines 20-26","start_line":20,"end_line":26,"excerpt":"## myricetin-microbial-deglycosylation\nGut processing produces a chemically different molecule.\nHuman-donor intestinal bacterial cultures yielded Myricetin through the reported deglycosylation route.\nModel: Four active isolates selected from about 100 colonies from one healthy female donor; most identified as Escherichia.\nLimitations: Mass-spectrometric pathway assignment; no specific enzyme or population-wide conversion rate established.\nEvidence access: Primary abstract\nIdentification of the metabolites of myricitrin produced by human intestinal bacteria in vitro using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24882500/ · DOI 10.1517/17425255.2014.918954","model_system":"Four active isolates selected from about 100 colonies from one healthy female donor; most identified as Escherichia.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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