{"id":"501acc5c-1726-5658-9b05-a011ea21ae20","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-sucrose-comparison","predicate":"no_detected_difference_from_sucrose","statement":"No measured metabolic outcome differed significantly between the HFCS and sucrose beverage groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"92f57091-482a-5922-a14f-1e13d043e241","mechanism_event_label":"No measured metabolic outcome differed significantly between the HFCS and sucrose beverage groups.","subject":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"object":{"id":"6c6119b5-1742-5646-a6da-2847b6902791","slug":"human-hfcs-sucrose-endocrine-comparison","display_name":"Human endocrine responses to HFCS versus sucrose","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"92f57091-482a-5922-a14f-1e13d043e241","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-sucrose-comparison-event","event_type":"observed_relationship","label":"No measured metabolic outcome differed significantly between the HFCS and sucrose beverage groups.","description":"No measured metabolic outcome differed significantly between the HFCS and sucrose beverage groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6c6119b5-1742-5646-a6da-2847b6902791","slug":"human-hfcs-sucrose-endocrine-comparison","display_name":"Human endocrine responses to HFCS versus sucrose","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"832b1926-18e7-5b76-8dc4-bad8ed234645","slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e0f8ea3d-6b7f-5bea-88fd-46f624947c6a","slug":"human-matsuda-insulin-sensitivity","display_name":"Human Matsuda insulin sensitivity index","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"c897f9af-e3c8-5626-96a1-71bcdc16cad4","slug":"human-hepatic-lipid-content","display_name":"Human hepatic lipid content measured by imaging","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"HFCS-55 or sucrose at 25% energy requirement versus aspartame; HFCS n=28, sucrose n=24, control n=23","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"16 days of beverages, approximately 2 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"75 adults in nonrandomized double-blinded matched beverage groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Direct HFCS-55 comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No random assignment; 66 paired MRI scans, including 23 HFCS. Liver-fat HFCS significance was versus baseline, not established versus aspartame. No detected HFCS-sucrose difference is not universal equivalence. HFCS/control lipid data overlap PMID 25904601.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"75 adults in nonrandomized double-blinded matched beverage groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"No measured metabolic outcome differed significantly between the HFCS and sucrose beverage groups.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. (2021). https://pubmed.ncbi.nlm.nih.gov/34265055/ DOI: 10.1210/clinem/dgab508","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral 3 servings/day; usual diet outpatient, isocaloric substitutions during inpatient testing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"MRI liver fat, oral-glucose-derived sensitivity, plasma markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"daf8de1c-2ab2-5c3a-8089-d62c3f69fdb3","evidence_kind":"source_excerpt","locator":"Lines 341-351","start_line":341,"end_line":351,"excerpt":"## hfcs-sucrose-comparison\nNo measured metabolic outcome differed significantly between the HFCS and sucrose beverage groups.\nModel/species: 75 adults in nonrandomized double-blinded matched beverage groups\nTissue: MRI liver fat, oral-glucose-derived sensitivity, plasma markers\nExposure: HFCS-55 or sucrose at 25% energy requirement versus aspartame; HFCS n=28, sucrose n=24, control n=23\nRoute: Oral 3 servings/day; usual diet outpatient, isocaloric substitutions during inpatient testing\nDuration: 16 days of beverages, approximately 2 weeks\nExposure scope: Direct HFCS-55 comparison\nLimits: No random assignment; 66 paired MRI scans, including 23 HFCS. Liver-fat HFCS significance was versus baseline, not established versus aspartame. No detected HFCS-sucrose difference is not universal equivalence. HFCS/control lipid data overlap PMID 25904601.\nReference: Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. (2021). https://pubmed.ncbi.nlm.nih.gov/34265055/ DOI: 10.1210/clinem/dgab508\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"75 adults in nonrandomized double-blinded matched beverage groups","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}