{"id":"500638fa-6721-5ea8-818a-110d28de17ea","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-atr","predicate":"inhibits","statement":"Caffeine inhibited the checkpoint kinase at concentrations associated with experimental radiosensitization.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"092899a3-f60a-55ac-b55a-ddbff4d662b7","mechanism_event_label":"Caffeine also has a laboratory DNA-damage-response target.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"fe8d147a-fd3c-5768-ae24-f6c4fbd2ae8d","slug":"atr","display_name":"Human ATR kinase","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"092899a3-f60a-55ac-b55a-ddbff4d662b7","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-atr-event","event_type":"observed_relationship","label":"Caffeine also has a laboratory DNA-damage-response target.","description":"Caffeine inhibited the checkpoint kinase at concentrations associated with experimental radiosensitization.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fe8d147a-fd3c-5768-ae24-f6c4fbd2ae8d","slug":"atr","display_name":"Human ATR kinase","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Kinase assays and irradiated A549 tumor-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pharmacological radiosensitization context; no claim that dietary caffeine inhibits human DNA repair or treats cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Caffeine also has a laboratory DNA-damage-response target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10485486/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8487df48-1735-5810-9cf6-f0e580051bc0","evidence_kind":"source_excerpt","locator":"Lines 420-426","start_line":420,"end_line":426,"excerpt":"## caf-atr\nCaffeine also has a laboratory DNA-damage-response target.\nCaffeine inhibited the checkpoint kinase at concentrations associated with experimental radiosensitization.\nModel: Kinase assays and irradiated A549 tumor-cell experiments.\nLimitations: Pharmacological radiosensitization context; no claim that dietary caffeine inhibits human DNA repair or treats cancer.\nEvidence access: Primary abstract\nInhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10485486/","model_system":"Kinase assays and irradiated A549 tumor-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}