{"id":"4f9dd369-99e3-5d79-a362-fa06b8ae4f13","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-tars2-rag-variants","predicate":"when_variant_reduces","statement":"Disease-associated variants within TARS2 residues 301–381 reduced Rag binding in vitro; the associated mTORC1 mechanism was also investigated in zebrafish.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2f9c0750-46e9-5861-8cf3-cd6054854f8e","mechanism_event_label":"Some variants can affect signaling as well as the usual translation function.","subject":{"id":"e1304998-8f29-56cc-8535-e65d11c53582","slug":"tars2","display_name":"Human mitochondrial threonyl-tRNA synthetase / TARS2","entity_type_key":"protein"},"object":{"id":"519f2585-dd2d-5585-afb7-769698a6aa48","slug":"human-tars2-rag-binding","display_name":"Human TARS2 binding to Rag GTPases","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2f9c0750-46e9-5861-8cf3-cd6054854f8e","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-tars2-rag-variants-event","event_type":"observed_relationship","label":"Some variants can affect signaling as well as the usual translation function.","description":"Disease-associated variants within TARS2 residues 301–381 reduced Rag binding in vitro; 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