{"id":"4f495ea8-6985-5f10-988a-1aca7d7aa855","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-starvation-p53-loss","predicate":"increases","statement":"p53-deficient cells failed to complete the adaptive response to serine withdrawal and developed oxidative stress, lower viability and impaired proliferation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7b4fbb17-cae6-583d-a624-eda5654bf262","mechanism_event_label":"The same shortage can have a different outcome when stress-response machinery is missing.","subject":{"id":"5a8dec46-8534-5173-a3f4-7fc40198410b","slug":"human-p53-deficient-serine-starvation","display_name":"Serine starvation in p53-deficient human cancer cells","entity_type_key":"cellular_process"},"object":{"id":"9e32ef8e-7668-57f1-9c0f-18e103f73df8","slug":"human-serine-starvation-oxidative-stress","display_name":"Oxidative stress during serine starvation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7b4fbb17-cae6-583d-a624-eda5654bf262","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-starvation-p53-loss-event","event_type":"observed_relationship","label":"The same shortage can have a different outcome when stress-response machinery is missing.","description":"p53-deficient cells failed to complete the adaptive response to serine withdrawal and developed oxidative stress, lower viability and impaired proliferation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5a8dec46-8534-5173-a3f4-7fc40198410b","slug":"human-p53-deficient-serine-starvation","display_name":"Serine starvation in p53-deficient human cancer cells","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9e32ef8e-7668-57f1-9c0f-18e103f73df8","slug":"human-serine-starvation-oxidative-stress","display_name":"Oxidative stress during serine starvation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cancer-cell p53 comparison, with an additional in-vivo tumor model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is not a proven dietary cancer therapy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same shortage can have a different outcome when stress-response machinery is missing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23242140/ · DOI 10.1038/nature11743","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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